Relationship of CYP3A5 genotype and ABCB1 diplotype to tacrolimus disposition in Brazilian kidney transplant patients

机译：CYP3A5基因型和ABCB1双型与他克莫司治疗的关系

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AimsTacrolimus (TAC) is one of the most successful immunosuppressive drugs in transplantation. Its pharmacokinetics (PK) and pharmacogenetics (PG) have been extensively studied, with many studies showing the influence of CYP3A5 on TAC metabolism and bioavailability. However, data concerning the functional significance of ABCB1 polymorphisms are uncertain due to inconsistent results. We evaluated the association between ABCB1 diplotypes, CYP3A5 polymorphisms and TAC disposition in a cohort of Brazilian transplant recipients.

机译：目的他克莫司（TAC）是移植中最成功的免疫抑制药物之一。它的药代动力学（PK）和药物遗传学（PG）已被广泛研究，许多研究表明CYP3A5对TAC代谢和生物利用度的影响。但是，由于结果不一致，有关ABCB1多态性功能意义的数据尚不确定。我们在一组巴西移植受者中评估了ABCB1双型，CYP3A5多态性和TAC处置之间的关联。

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期刊名称 British Journal of Clinical Pharmacology
作者
Diego Alberto C Cusinato; Riccardo Lacchini; Elen A Romao; Miguel Moysés-Neto; Eduardo B Coelho;
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作者单位

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年(卷),期 2014(78),2
年度 2014
页码 364–372
总页数 9
原文格式 PDF
正文语种
中图分类药学;
关键词
ABCB1 diplotype cytochrome P450 kidney transplantation pharmacogenetics tacrolimus pharmacokinetics;

机译：ABCB1双倍型;细胞色素P450;肾脏移植;药物遗传学;他克莫司药代动力学;

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专利

1. Relationship of CYP3A5 genotype and ABCB1 diplotype to tacrolimus disposition in Brazilian kidney transplant patients [J] . CusinatoD.A.C., LacchiniR., RomaoE.A., British Journal of Clinical Pharmacology . 2014,第2期

机译：CYP3A5基因型和ABCB1双型与他克莫司治疗的关系
2. Relationship of CYP3A5 genotype and ABCB1 diplotype to tacrolimus disposition in Brazilian kidney transplant patients [J] . Cusinato Diego Alberto C., Lacchini Riccardo, Romao Elen A., British journal of clinical pharmacology . 2014,第2期

机译：CYP3A5基因型和ABCB1双型与他克莫司治疗的关系
3. Effect of ABCB1 diplotype on tacrolimus disposition in renal recipients depends on CYP3A5 and CYP3A4 genotype [J] . Vanhove T., Annaert P., Lambrechts D., The pharmacogenomics journal . 2017,第6期

机译：ABCB1 Diplotype对肾脏受体中Tacolimus倾向的影响取决于CYP3A5和CYP3A4基因型
4. Influence of CYP3A5 polymorphism on tacrolimus blood concentrations in renal transplant patients [C] . NIE Xin-min, GUI Rong, ZHAO Hong-shan, Postdoctoral Symposium for Celebration of 20th Anniversary of the Foundation of Chinese Postdoctoral System; 2005; . 2005

机译：CYP3A5基因多态性对肾移植患者他克莫司血药浓度的影响
5. ABCB1 and IMPDH functional and genetic contributions to tacrolimus and mycophenolic acid therapy in transplant patients [D] . Wang, Jian. 2007

机译：ABCB1和IMPDH在他克莫司和麦考酚酸治疗中的功能和遗传贡献
6. A non-randomized trial of conversion from ciclosporin and tacrolimus to tacrolimus MR4 in stable long-term kidney transplant recipients: Graft function and influences of ABCB1 genotypes [O] . Markus Riegersperger, Max Plischke, Anita Jallitsch-Halper, 2012

机译：在稳定的长期肾脏移植受者中从环孢菌素和他克莫司转化为他克莫司MR4的非随机试验：移植功能和ABCB1基因型的影响
7. Relationship ofCYP3A5genotype andABCB1diplotype to tacrolimus disposition in Brazilian kidney transplant patients [O] . Diego Alberto C. Cusinato, Riccardo Lacchini, Elen A. Romao, 2014

机译：Brazilian肾移植患者的Cyp3a5Genotype Andabcb1dimp1diplotype的关系

Relationship of CYP3A5 genotype and ABCB1 diplotype to tacrolimus disposition in Brazilian kidney transplant patients

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