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Thiopurine methyltransferase genotype–phenotype discordance and thiopurine active metabolite formation in childhood acute lymphoblastic leukaemia

机译：儿童急性淋巴细胞白血病中硫嘌呤甲基转移酶基因型-表型不一致和硫嘌呤活性代谢物形成

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摘要

AimsIn children with acute lymphoblastic leukaemia (ALL) bone marrow activity can influence red blood cell (RBC) kinetics, the surrogate tissue for thiopurine methyltransferase (TPMT) measurements. The aim of this study was to investigate TPMT phenotype–genotype concordance in ALL, and the influence of TPMT on thiopurine metabolite formation.

机译：目的在患有急性淋巴细胞白血病（ALL）的儿童中，骨髓活动可影响红细胞（RBC）动力学，是硫代嘌呤甲基转移酶（TPMT）测量的替代组织。本研究的目的是研究ALL中TPMT的表型-基因型一致性，以及TPMT对硫嘌呤代谢物形成的影响。

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期刊名称 British Journal of Clinical Pharmacology
作者
Lynne Lennard; Cher Suzanne Cartwright; Rachel Wade; Susan M Richards; Ajay Vora;
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作者单位

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年(卷),期 2013(76),1
年度 2013
页码 125–136
总页数 12
原文格式 PDF
正文语种
中图分类药学;
关键词
childhood leukaemia genotype–phenotype discordance mercaptopurine thioguanine thioguanine nucleotides thiopurine methyltransferase;

机译：儿童白血病;基因型-表型不一致;巯基嘌呤;硫鸟嘌呤;硫鸟嘌呤核苷酸;硫嘌呤甲基转移酶;

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专利

1. Thiopurine methyltransferase genotype–phenotype discordance and thiopurine active metabolite formation in childhood acute lymphoblastic leukaemia [J] . Lynne Lennard, Cher Suzanne Cartwright, Rachel Wade, British journal of clinical pharmacology . 2013,第1期

机译：儿童急性淋巴细胞白血病中硫嘌呤甲基转移酶基因型-表型不一致和硫嘌呤活性代谢物形成
2. Thiopurine dose intensity and treatment outcome in childhood lymphoblastic leukaemia: the influence of thiopurine methyltransferase pharmacogenetics [J] . Lennard Lynne, Cartwright Cher S., Wade Rachel, British Journal of Haematology . 2015,第2期

机译：硫嘌呤的剂量强度和儿童淋巴母细胞白血病的治疗结果：硫嘌呤甲基转移酶药物遗传学的影响
3. Incorporation of 6-thioguanine nucleotides into DNA during maintenance therapy of childhood acute lymphoblastic leukemia-the influence of thiopurine methyltransferase genotypes [J] . EbbesenM.S., NerstingJ., JacobsenJ.H., The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2013,第6期

机译：在儿童急性淋巴细胞白血病的维持治疗中将6-硫鸟嘌呤核苷酸掺入DNA-硫嘌呤甲基转移酶基因型的影响
4. Thiopurine Metabolites Analysis: The Diagnostic Companion Test to the Genotypic and Phenotypic Thiopurine Methyltransferase Assays [C] . Stacy Dee, Yvonne Wright, Russell Grant American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：Thiopurine代谢物分析：对基因型和表型硫嘌呤甲基转移酶测定的诊断伴伴试验
5. Pharmacogenetics of thiopurine- and etoposide-induced malignancies in childhood acute lymphoblastic leukemia. [D] . Edick, Mathew James. 2003

机译：儿童急性淋巴细胞白血病中硫嘌呤和依托泊苷诱导的恶性肿瘤的药理遗传学。
6. Thiopurine dose intensity and treatment outcome in childhood lymphoblastic leukaemia: the influence of thiopurine methyltransferase pharmacogenetics [O] . Lynne Lennard, Cher S. Cartwright, Rachel Wade, -1

机译：儿童淋巴细胞白血病中硫嘌呤的剂量强度和治疗效果：硫嘌呤甲基转移酶药理学的影响
7. Thiopurine methyltransferase genotype-phenotype discordance and thiopurine active metabolite formation in childhood acute lymphoblastic leukaemia. [O] . Lennard, L, Cartwright, CS, Wade, R, 2013

机译：儿童急性淋巴细胞白血病中硫嘌呤甲基转移酶基因型-表型不一致和硫嘌呤活性代谢物形成。

Thiopurine methyltransferase genotype–phenotype discordance and thiopurine active metabolite formation in childhood acute lymphoblastic leukaemia

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