The effects of two antidepressant agents on performance on the Stroop Colour-Word test in normal male volunteer subjects

摘要

>1 Healthy male volunteers were given either imipramine (25 mgs three times a day), viloxazine hydrochloride (Vivalan) (50 mgs three times a day), placebo or no tablets on a double-blind basis.>2 Subjects took the tablets for 7 days, and were tested before treatment and then after 1, 7 and 21 doses.>3 The Stroop Colour-Word test was used to assess performance.>4 While no significant drug effects were found it is suggested that some of the trends shown are indicative of a slight worsening of performance with imipramine and a slight improvement with viloxazine hydrochloride after seven doses.