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Therapeutic targeting of erbB3 with MM-121/SAR256212 enhances antitumor activity of paclitaxel against erbB2-overexpressing breast cancer

机译：MM-121 / SAR256212对erbB3的治疗靶向增强紫杉醇对过表达erbB2的乳腺癌的抗肿瘤活性

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IntroductionElevated expression of erbB3 rendered erbB2-overexpressing breast cancer cells resistant to paclitaxel via PI-3 K/Akt-dependent upregulation of Survivin. It is unclear whether an erbB3-targeted therapy may abrogate erbB2-mediated paclitaxel resistance in breast cancer. Here, we study the antitumor activity of an anti-erbB3 antibody MM-121/SAR256212 in combination with paclitaxel against erbB2-overexpressing breast cancer.

机译：引言通过PI-3 K / Akt依赖性Survivin的上调，erbB3的表达升高使erbB2过表达的乳腺癌细胞对紫杉醇具有抗性。尚不清楚靶向erbB3的疗法是否可以消除乳腺癌中erbB2介导的紫杉醇耐药性。在这里，我们研究了抗-erbB3抗体MM-121 / SAR256212与紫杉醇联用对erbB2过表达乳腺癌的抗肿瘤活性。

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期刊名称 Breast Cancer Research : BCR
作者
Shuiliang Wang; Jingcao Huang; Hui Lyu; Bo Cai; Xiaoping Yang; Fang Li; Jianming Tan; Susan M Edgerton; Ann D Thor; Choon-Kee Lee; Bolin Liu;
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作者单位

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年(卷),期 2013(15),5
年度 2013
页码 R101
总页数 13
原文格式 PDF
正文语种
中图分类肿瘤学;
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专利

1. Therapeutic targeting of erbB3 with MM-121/SAR256212 enhances antitumor activity of paclitaxel against erbB2-overexpressing breast cancer [J] . Shuiliang Wang, Jingcao Huang, Hui Lyu, Breast Cancer Research . 2013,第5期

机译：MM-121 / SAR256212对erbB3的治疗靶向增强紫杉醇对erbB2过表达的乳腺癌的抗肿瘤活性
2. The anti-erbB3 antibody MM-121/SAR256212 in combination with trastuzumab exerts potent antitumor activity against trastuzumab-resistant breast cancer cells [J] . Jingcao Huang, Shuiliang Wang, Hui Lyu, Molecular Cancer . 2013,第1期

机译：抗-erbB3抗体MM-121 / SAR256212与曲妥珠单抗组合可对抗曲妥珠单抗的乳腺癌细胞产生有效的抗肿瘤活性
3. Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers. [J] . Raja SM, Clubb RJ, Ortega Cava C, Cancer biology & therapy . 2011,第2期

机译：Celastrol与针对ErbB2的过度表达乳腺癌的靶向治疗药物联合使用的抗癌活性。
4. Therapeutic ultrasound microbubbles carrying paclitaxel and LyP-1 peptide: Preparation, characterization and application to ultrasonic assisted chemotherapy in breast cancer cells [C] . Yan Fei, Li Xiang, Jin Qiaofeng, 2010 IEEE International Ultrasonics Symposium . 2010

机译：载有紫杉醇和LyP-1肽的治疗性超声微泡：乳腺癌细胞超声辅助化学疗法的制备，表征和应用
5. Enhancement of Gemcitabine and Paclitaxel Uptake and Retention in Metastatic Cancer Cells: A Novel Targeted Combination Delivery Approach to Eliminate Breast Cancer in Blood and Lymph [D] . Yu, Jesse. 2020

机译：吉西他滨和紫杉醇吸收的增强和转移性癌细胞的保留：一种小型靶向组合递送方法，消除血液和淋巴中的乳腺癌
6. The anti-erbB3 antibody MM-121/SAR256212 in combination with trastuzumab exerts potent antitumor activity against trastuzumab-resistant breast cancer cells [O] . Jingcao Huang, Shuiliang Wang, Hui Lyu, 2013

机译：抗-erbB3抗体MM-121 / SAR256212与曲妥珠单抗组合可对抗曲妥珠单抗的乳腺癌细胞产生有效的抗肿瘤活性
7. Therapeutic targeting of erbB3 with MM-121/SAR256212 enhances antitumor activity of paclitaxel against erbB2-overexpressing breast cancer [O] . Shuiliang Wang, Jingcao Huang, Hui Lyu, 2013

机译：MM-121 / SAR256212对erbB3的治疗靶向增强紫杉醇对过表达erbB2的乳腺癌的抗肿瘤活性

Therapeutic targeting of erbB3 with MM-121/SAR256212 enhances antitumor activity of paclitaxel against erbB2-overexpressing breast cancer

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