Anti-tumor activity and toxicokinetics analysis of MGAH22 an anti-HER2 monoclonal antibody with enhanced Fcγ receptor binding properties

摘要

IntroductionResponse to trastuzumab in metastatic breast cancer correlates with expression of the high binding variant (158V) of the activating Fcγ receptor IIIA (CD16A). We engineered MGAH22, a chimeric anti-HER2 monoclonal antibody with specificity and affinity similar to trastuzumab, with an Fc domain engineered for increased binding to both alleles of human CD16A.