It has been brought to our attention that there was an inaccuracy in the above article []. In the discussion section the authors state that "One of the assumptions underlying mammary transplant studies is that mammary outgrowths at limiting dilution are clonal (14,000–20,000 cells per cleared fat pad)" and they attribute this to reference 21 "Smith GH: Experimental mammary epithelial morphogenesis in an in vivo model: evidence for distinct cellular progenitors of the ductal and lobular phenotype. Breast Cancer Res Treat 1996, 39:21–31" []. In the paper by Smith no claim of clonality is made, rather it is stated that it is not known whether the simultaneous development of both lobular and ductal phenotypes indicates cooperative interaction between the two epithelial progenitors or signals the presence of a third progenitor type capable of producing both ductular and lobular committed daughters. It is, therefore, incorrect that the assumption of clonality based on limiting dilution has been attributed to Gilbert Smith.
展开▼
机译：提请我们注意的是，以上文章[]中存在错误。在讨论部分中，作者指出：“进行乳腺移植研究的一个假设是，有限稀释的乳腺产物是克隆的（每个清除的脂肪垫有14,000–20,000个细胞）”，他们将此归因于参考文献21“ Smith GH：实验性乳腺体内模型中的上皮形态发生：导管和小叶表型的不同细胞祖细胞的证据。《乳腺癌研究》，1996，39：21-31“ []。在Smith的论文中，没有提出克隆性的主张，而是指出，尚不知道小叶表型和导管表型的同时发展是否表明两个上皮祖细胞之间的协同相互作用，或者预示着能够分化的第三种祖细胞的存在。产生导管和小叶致力于女儿。因此，基于吉尔伯特·史密斯（Gilbert Smith）得出的基于有限稀释度的克隆性假设是不正确的。
展开▼
