2013 Poster Presentations / Séances de présentation d’affiches

摘要

RATIONALE:Cell migration is an important biological mechanism that is involved in the pathophysiology of several diseases, such as asthma. Chemokines and their receptors are essential for induction of inflammatory and/or structural cell migration. We previously established that IL-17 induced growth-related oncogenes (GROα, GROβ and GROγ) can promote human airway smooth muscle cell (ASMC) migration in an auto-crine fashion. This effect was mediated through their putative receptor, the CXCR2 receptor. In this study we aimed to investigate the particular effects of GRO-α on ASMC migration and the mechanism(s) by which this migration is mediated..