Deguelin induces apoptosis in colorectal cancer cells by activating the p38 MAPK pathway

机译：Deguelin通过激活p38 MAPK途径诱导大肠癌细胞凋亡

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ObjectivesDeguelin, a rotenoid extracted from Mundulea sericea (Leguminosae), exhibits antitumor effects on several types of human cancers. Due to the limited studies of deguelin on colorectal cancer (CRC), the present study was designed to investigate the antitumor effect of deguelin and to explore the underlying mechanism in CRC.

机译：目的Deguelin是一种从Mundulea sericea（豆科）中提取的类胡萝卜素，对几种类型的人类癌症均表现出抗肿瘤作用。由于德古林对结直肠癌（CRC）的研究有限，因此本研究旨在研究德古林的抗肿瘤作用并探讨其在CRC中的潜在机制。

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期刊名称 Cancer Management and Research
作者
Liubo Chen; Kai Jiang; Haiyan Chen; Yang Tang; Xinyi Zhou; Yinuo Tan; Ying Yuan; Qian Xiao; Kefeng Ding;
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作者单位

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年(卷),期 2019(11),-1
年度 2019
页码 95–105
总页数 11
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
deguelin colorectal cancer apoptosis p38 MAPK pathway;

机译：德盖林;结直肠癌;细胞凋亡;p38 MAPK途径;

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专利

1. Deguelin induces apoptosis in colorectal cancer cells by activating the p38 MAPK pathway [J] . Liubo Chen, Kai Jiang, Haiyan Chen, Cancer Management and Research . 2018,第1期

机译：Deguelin通过激活p38 MAPK途径诱导大肠癌细胞凋亡
2. Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways [J] . Minh Truong Do, MinKyun Na, Hyung Gyun Kim Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research . 2014,第Null期

机译：Ilimaquinone诱导死亡受体表达，并通过激活ROS-ERK / p38 MAPK-CHOP信号通路使人结肠癌细胞对TRAIL诱导的细胞凋亡敏感
3. Extract of Lactobacillus plantarum strain 06CC2 induces JNK/p38 MAPK pathway-mediated apoptosis through endoplasmic reticulum stress in Caco2 colorectal cancer cells [J] . Nobuhiro Hiraishi, Shuji Kanmura, Kouhei Oda, Biochemistry and Biophysics Reports . 2019,第1期

机译：植物乳杆菌 ce：italic 菌株06CC2提取物通过内质网应激诱导JNK / p38 MAPK途径介导的细胞凋亡在Caco2结直肠癌细胞中的作用
4. Sensitization of human colorectal cancer cells to paclitaxel- induced apoptosis by inhibition of MEK/ERK pathway is caspase-4 dependent [C] . NIZAR M. MHAIDAT, SAIED A. JARADAT, ABDULHAMEED GHABKARI Recent researches in modern medicine . 2011

机译：通过抑制MEK / ERK途径使大肠癌细胞对紫杉醇诱导的细胞凋亡的敏感性取决于caspase-4
5. Investigation of Inducible Mitogen and Stress Activated Protein Kinase 1 (MSK1) and Histone H3 Phosphorylation by the RAS-MAPK Pathway in Cancer Cells. [D] . Espino, Paula. 2010

机译：通过癌细胞中的RAS-MAPK途径研究诱导型丝裂原和应激激活的蛋白激酶1（MSK1）和组蛋白H3磷酸化。
6. Extract of Lactobacillus plantarum strain 06CC2 induces JNK/p38 MAPK pathway-mediated apoptosis through endoplasmic reticulum stress in Caco2 colorectal cancer cells [O] . Nobuhiro Hiraishi, Shuji Kanmura, Kouhei Oda, 2019

机译：植物乳杆菌菌株06CC2的提取物通过内质网应激在Caco2大肠癌细胞中诱导JNK / p38 MAPK途径介导的凋亡
7. Deguelin induces apoptosis in colorectal cancer cells by activating the p38 MAPK pathway [O] . Liubo Chen, Kai Jiang, Haiyan Chen, 2018

机译：Deguelin通过激活P38 Mapk途径诱导结肠直肠癌细胞的细胞凋亡

Deguelin induces apoptosis in colorectal cancer cells by activating the p38 MAPK pathway

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