Up-regulation of the DR5 Expression by Proteasome Inhibitor MG132 Augments TRAIL-Induced Apoptosis in Soft Tissue Sarcoma Cell Lines

机译：蛋白酶体抑制剂MG132对DR5表达的上调增强了TRAIL诱导的软组织肉瘤细胞株的凋亡。

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PurposeCurrent chemotherapeutics for treating locally advanced or metastatic soft tissue sarcomas (STS) are limited. Accordingly, the present in vitro study was conducted to evaluate the effects of treatment of STS cells with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) applied as a single agent or in combination with a proteasome inhibitor, MG132.

机译：目的目前用于治疗局部晚期或转移性软组织肉瘤（STS）的化学疗法是有限的。因此，进行了本体外研究以评价以单一药剂或与蛋白酶体抑制剂MG132组合使用的肿瘤坏死因子相关凋亡诱导配体（TRAIL）对STS细胞的治疗效果。

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期刊名称 Cancer Research and Treatment : Official Journal of Korean Cancer Association
作者
Hee-Jeong Cheong; Kyu Sang Lee; In Sook Woo; Jong-Ho Won; Jae Ho Byun;
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作者单位

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年(卷),期 2011(43),2
年度 2011
页码 124–130
总页数 7
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
TNF-related apoptosis-inducing ligand MG 132 Soft tissue sarcoma Apoptosis;

机译：肿瘤坏死因子相关的凋亡诱导配体;MG 132;软组织肉瘤;细胞凋亡;

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专利

1. Proteasome inhibitor MG132 potentiates TRAIL-induced apoptosis in gallbladder carcinoma GBC-SD cells via DR5-dependent pathway [J] . Zhu Weiping, Zhan Dihua, Wang Lu, Oncology reports . 2016,第2期

机译：蛋白酶体抑制剂MG132通过DR5依赖性途径增强TRAIL诱导的胆囊癌GBC-SD细胞凋亡
2. p53-Independent up-regulation of a TRAIL receptor DR5 by proteasome inhibitors: a mechanism for proteasome inhibitor-enhanced TRAIL-induced apoptosis. [J] . Seol DW Biochemical and Biophysical Research Communications . 2011,第1a2期

机译：蛋白酶体抑制剂对p53的TRAIL受体DR5的独立依赖性上调：蛋白酶体抑制剂增强TRAIL诱导的细胞凋亡的机制。
3. Quercetin sensitizes human hepatoma cells to TRAIL-induced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPS down-regulation. [J] . Kim JY, Kim EH, Park SS, Journal of cellular biochemistry. . 2008,第6期

机译：槲皮素通过Sp1介导的DR5上调和蛋白酶体介导的c-FLIPS下调使人肝癌细胞对TRAIL诱导的凋亡敏感。
4. Bcl-2 overexpression Inhibits TRAIL-induced Apoptosis in Type II Cells [C] . S. Fulda, K.-M. Debatin European Haematology Association . 2002

机译：Bcl-2过表达抑制II型细胞中的血迹诱导的细胞凋亡
5. The effect of a selective COX-2 inhibitor, celecoxib, on the proliferation, apoptosis and differential protein expression in nasopharyngeal carcinoma cell lines. [D] . Chan, Ming Lok. 2008

机译：选择性COX-2抑制剂塞来昔布对鼻咽癌细胞系中增殖，凋亡和差异蛋白表达的影响。
6. Pentoxifylline and the proteasome inhibitor MG132 induce apoptosis in human leukemia U937 cells through a decrease in the expression of Bcl-2 and Bcl-XL and phosphorylation of p65 [O] . Alejandro Bravo-Cuellar, Georgina Hernández-Flores, José Manuel Lerma-Díaz, 2013

机译：己酮可可碱和蛋白酶体抑制剂MG132通过降低Bcl-2和Bcl-XL的表达以及p65的磷酸化来诱导人白血病U937细胞凋亡
7. Up-regulation of the DR5 Expression by Proteasome Inhibitor MG132 Augments TRAIL-Induced Apoptosis in Soft Tissue Sarcoma Cell Lines [O] . Cheong, Hee-Jeong, Lee, Kyu Sang, Woo, In Sook, 2011

机译：蛋白酶体抑制剂MG132对DR5表达的上调增强了TRAIL诱导的软组织肉瘤细胞株的凋亡。
8. Cloning and Characterization of Genes That Inhibit TRAIL-Induced Apoptosis of Breast Cancer Cells [R] . Shu, H. 2004

机译：抑制TRaIL诱导乳腺癌细胞凋亡的基因的克隆与鉴定

Up-regulation of the DR5 Expression by Proteasome Inhibitor MG132 Augments TRAIL-Induced Apoptosis in Soft Tissue Sarcoma Cell Lines

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