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The role of apoptosis repressor with a CARD domain (ARC) in the therapeutic resistance of renal cell carcinoma (RCC): the crucial role of ARC in the inhibition of extrinsic and intrinsic apoptotic signalling

机译：具有CARD域（ARC）的凋亡抑制因子在肾细胞癌（RCC）的治疗抗性中的作用：ARC在抑制外在和内在凋亡信号传导中的关键作用

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BackgroundRenal cell carcinomas (RCCs) display broad resistance against conventional radio- and chemotherapies, which is due at least in part to impairments in both extrinsic and intrinsic apoptotic pathways. One important anti-apoptotic factor that is strongly overexpressed in RCCs and known to inhibit both apoptotic pathways is ARC (apoptosis repressor with a CARD domain).

机译：背景肾细胞癌（RCC）对常规放射疗法和化学疗法表现出广泛的抵抗力，这至少部分是由于外在和内在的凋亡途径均受损。在RCC中强烈过度表达并抑制两种凋亡途径的一种重要的抗凋亡因子是ARC（具有CARD域的凋亡抑制因子）。

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期刊名称 Cell Communication and Signaling : CCS
作者
Csaba Toth; Sarah Funke; Vanessa Nitsche; Anna Liverts; Viktoriya Zlachevska; Marcia Gasis; Constanze Wiek; Helmut Hanenberg; Csaba Mahotka; Peter Schirmacher; Sebastian Heikaus;
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作者单位

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年(卷),期 2017(15),-1
年度 2017
页码 16
总页数 14
原文格式 PDF
正文语种
中图分类细胞生物学;
关键词
ARC Apoptosis Bcl-2 family renal cell carcinoma (RCC) ABT-263 TRAIL;

机译：ARC;凋亡;Bcl-2家族;肾细胞癌（RCC）;ABT-263;TRAIL;

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1. The role of apoptosis repressor with a CARD domain (ARC) in the therapeutic resistance of renal cell carcinoma (RCC): the crucial role of ARC in the inhibition of extrinsic and intrinsic apoptotic signalling [J] . Csaba Toth, Sarah Funke, Vanessa Nitsche, Cell Communication and Signaling . 2017,第1期

机译：具有CARD域（ARC）的凋亡抑制因子在肾细胞癌（RCC）的治疗抵抗中的作用：ARC在抑制外在和内在凋亡信号中的关键作用
2. Synergistic roles of p53 and HIF1α in human renal cell carcinoma-cell apoptosis responding to the inhibition of mTOR and MDM2 signaling pathways [J] . Qing-jun Liu, Hong-liang Shen, Jun Lin, Drug Design, Development and Therapy . 2016,第5期

机译：p53和HIF1α在响应mTOR和MDM2信号通路抑制的人肾癌细胞凋亡中的协同作用
3. Renal cell carcinoma: Resistance to therapy, role of apoptosis, and the prognostic and therapeutic target potential of TRAF proteins [J] . RajandramR., BennettN.C., MoraisC., Medical hypotheses . 2012,第2期

机译：肾细胞癌：TRAF蛋白对治疗的抗性，细胞凋亡的作用以及预后和治疗的靶标潜力
4. Caspase Activation and Extracellular Signal-Regulated Kinase/Akt Inhibition Were Involved in Luteolin-Induced Apoptosis in Lewis Lung Carcinoma Cells [C] . JIN-HYUNG KIM, EUN-OK LEE, HYO-JUNG LEE, Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：半胱氨酸天冬氨酸蛋白酶激活和细胞外信号调节激酶/ Akt抑制涉及路易斯-肺癌细胞中木犀草素诱导的细胞凋亡。
5. Phosphatidylinositol Remodeling Through Membrane Bound O-Acyl Transferase Domain-7 (MBOAT7) Promotes the Progression of Clear Cell Renal Cell Carcinoma (ccRCC) [D] . Neumann, Chase K. A. 2020

机译：通过膜结合的磷脂酰肌醇通过膜结合O-酰基转移酶结构域-7（MBOAT7）促进透明细胞肾细胞癌的进展（CCRCC）
6. Synergistic roles of p53 and HIF1α in human renal cell carcinoma-cell apoptosis responding to the inhibition of mTOR and MDM2 signaling pathways [O] . Qing-jun Liu, Hong-liang Shen, Jun Lin, 2016

机译：p53和HIF1α在响应mTOR和MDM2信号通路抑制的人肾癌细胞凋亡中的协同作用
7. The role of apoptosis repressor with a CARD domain (ARC) in the therapeutic resistance of renal cell carcinoma (RCC): the crucial role of ARC in the inhibition of extrinsic and intrinsic apoptotic signalling [O] . Toth, Csaba, Funke, Sarah, Nitsche, Vanessa, 2017

机译：具有CARD结构域（ARC）的凋亡抑制因子在肾细胞癌（RCC）的治疗抵抗中的作用：ARC在抑制外在和内在凋亡信号传导中的关键作用

The role of apoptosis repressor with a CARD domain (ARC) in the therapeutic resistance of renal cell carcinoma (RCC): the crucial role of ARC in the inhibition of extrinsic and intrinsic apoptotic signalling

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