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Fibroblast-derived CXCL12 regulates PTEN expression and is associated with the proliferation and invasion of colon cancer cells via PI3k/Akt signaling

机译：成纤维细胞衍生的CXCL12调节PTEN表达并通过PI3k / Akt信号传导与结肠癌细胞的增殖和侵袭有关

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BackgroundStromal-derived CXCL12 play an important role which influence the proliferation and invasiveness of colon cancer in microenvironment. The present study aimed to analyze the underlying mechanism by which CXCL12 and tumour suppressor protein phosphatase and tensin homologue deleted on chromosome 10 (PTEN) influences the metastatic potential of colon cancer and internal relation of colon cancer and stromal cells.

机译：背景源性CXCL12在微环境中起重要作用，影响结肠癌的增殖和侵袭性。本研究旨在分析在第10号染色体（PTEN）上缺失的CXCL12和肿瘤抑制蛋白磷酸酶和张力蛋白同源物影响结肠癌转移潜力以及结肠癌与基质细胞内部关系的潜在机制。

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期刊名称 Cell Communication and Signaling : CCS
作者
Jiachi Ma; Xiaowen Sun; Yimin Wang; Bangling Chen; Liyu Qian; Yaguo Wang;
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作者单位

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年(卷),期 2019(17),-1
年度 2019
页码 119
总页数 12
原文格式 PDF
正文语种
中图分类细胞生物学;
关键词
Colorectal cancer CXCL12/SDF-1α PTEN Proliferation Invasiveness;

机译：大肠癌;CXCL12 /SDF-1α;PTEN;增殖;侵袭性;

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专利

1. Fibroblast-derived CXCL12 regulates PTEN expression and is associated with the proliferation and invasion of colon cancer cells via PI3k/Akt signaling [J] . Jiachi Ma, Xiaowen Sun, Yimin Wang, Cell Communication and Signaling . 2019,第1期

机译：成纤维细胞衍生的CXCL12调节PTEN表达，并通过PI3k / Akt信号传导与结肠癌细胞的增殖和侵袭有关
2. Fibroblast-derived CXCL12 regulates PTEN expression and is associated with the proliferation and invasion of colon cancer cells via PI3k/Akt signaling [J] . Jiachi Ma, Xiaowen Sun, Yimin Wang, Cell Communication and Signaling . 2019,第1期

机译：成纤维细胞衍生的CXCL12调节PTEN表达，并通过PI3k / Akt信号传导与结肠癌细胞的增殖和侵袭有关
3. mir-106a regulates cell proliferation and apoptosis of colon cancer cells through targeting the PTEN/PI3K/AKT signaling pathway [J] . Qin Yan, Huo Zhibin, Song Xiang, Oncology letters . 2018,第3aPta1期

机译：MiR-106A通过靶向PTEN / PI3K / AKT信号通路来调节结肠癌细胞的细胞增殖和凋亡
4. Ang-2 promoting proliferation of SW1116 colon cancer cells through PI3K/Akt pathways [C] . Hong Zhang Ji, Yang Wen Chun, Ping Wang Ai, 2011 International Conference on Human Health and Biomedical Engineering . 2011

机译：Ang-2通过PI3K / Akt途径促进SW1116结肠癌细胞的增殖
5. p90/CIP2A regulates lung cancer cell proliferation and cell apoptosis via the AKT signaling pathway. [D] . Lei, Ningjing. 2014

机译：p90 / CIP2A通过AKT信号通路调节肺癌细胞的增殖和细胞凋亡。
6. mir-106a regulates cell proliferation and apoptosis of colon cancer cells through targeting the PTEN/PI3K/AKT signaling pathway [O] . Yan Qin, Zhibin Huo, Xiang Song, -1

机译：mir-106a通过靶向PTEN / PI3K / AKT信号通路调节结肠癌细胞的增殖和凋亡
7. Fibroblast-derived CXCL12 regulates PTEN expression and is associated with the proliferation and invasion of colon cancer cells via PI3k/Akt signaling [O] . Jiachi Ma, Xiaowen Sun, Yimin Wang, 2019

机译：成纤维细胞衍生的CXCL12调节PTEN表达，与通过PI3K / AKT信号传导的结肠癌细胞的增殖和侵袭有关

Fibroblast-derived CXCL12 regulates PTEN expression and is associated with the proliferation and invasion of colon cancer cells via PI3k/Akt signaling

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