Cx43 phosphorylation on S279/282 and intercellular communication are regulated by IP3/IP3 receptor signaling

摘要

BackgroundInositol 1,4,5-trisphosphate receptor (IP3R) plays a pivotal role in the Ca²⁺ release process in a variety of cell types. Additionally, IP3R is distributed in ventricular intercalated discs, but its function(s) in this particular site remains unknown. Connexin (Cx43), the predominant gap junction (GJ) protein in ventricular myocardium, is linked to several signaling pathways that regulate Cx43 properties by (de)phosphorylation on multiple residues. Here, we investigated the regulatory role of IP3R in cell-cell communication and the mechanism(s) underlying this effect.