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Are Dietary Cholesterol Intake and Serum Cholesterol Levels Related to Nonalcoholic Fatty Liver Disease in Obese Children?

机译:肥胖儿童的饮食胆固醇摄入和血清胆固醇水平是否与非酒精性脂肪肝相关?

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摘要

Background. Nonalcoholic fatty liver disease (NAFLD) in children has been recognized as a major health burden. Serum lipids as well as dietary cholesterol (DC) intake may positively relate to development of NAFLD. The purpose of this study was to investigate anthropometric, biochemical, and dietary intake parameters of obese Greek children with and without NAFLD. Materials and Methods. Eighty-five obese children aged 8–15 (45 boys/40 girls) participated in the study. NAFLD was diagnosed by ultrasonography (US) in all subjects. Liver indexes were measured in all children. A 3-day dietary was recorded for all subjects. Results. 38 out of 85 children (44.7%) were found to have fatty liver. Obese children with increased levels of TC (95% CI: 1.721–3.191), low density lipoprotein (LDL) (95% CI: 1.829–3.058), and increased dietary cholesterol intakes (95% CI: 1.511–2.719) were 2.541, 2.612, and 2.041 times more likely to develop NAFLD compared with the children without NAFLD. Conclusion. The present study showed that TC, LDL, and DC were the strongest risk factors of development of NAFLD. Reducing body weight and dietary cholesterol intakes as well as decreasing serum TC and LDL levels are urgently necessary in order to prevent NAFLD and possible other health implications later in life.
机译:背景。儿童非酒精性脂肪肝疾病(NAFLD)已被视为主要的健康负担。血清脂质以及饮食中胆固醇(DC)的摄入可能与NAFLD的发生呈正相关。这项研究的目的是调查有或没有NAFLD的肥胖希腊儿童的人体测量,生化和饮食摄入参数。材料和方法。八十五岁的8-15岁肥胖儿童(45个男孩/ 40个女孩)参加了这项研究。通过超声(美国)在所有受试者中诊断出NAFLD。在所有儿童中测量肝指数。记录所有受试者的3天饮食。结果。 85名儿童中有38名(44.7%)被发现患有脂肪肝。肥胖儿童的TC水平(95%CI:1.721–3.191),低密度脂蛋白(LDL)(95%CI:1.829–3.058)和饮食胆固醇摄入增加(95%CI:1.511–2.719)分别为2.541,与没有NAFLD的儿童相比,发展NAFLD的可能性高2.612倍和2.041倍。结论。本研究表明TC,LDL和DC是NAFLD发生的最强危险因素。迫切需要减少体重和饮食中胆固醇的摄入,并降低血清TC和LDL水平,以预防NAFLD以及以后生活中可能对健康产生的其他影响。

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