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High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16 MLH1 and MGMT in elderly Chileans

机译：智利老年人体内高水平的循环叶酸浓度与抑癌基因和修复基因p16MLH1和MGMT的DNA甲基化有关

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BackgroundChanges in DNA methylation, one of the most studied epigenetic mechanisms, are considered an initial marker for early cancer detection. We evaluated how availability of dietary factors (folates and vitamin B12) involved in one-carbon metabolism may contribute to DNA methylation changes of cancer-related genes in human subjects.

机译：背景技术DNA甲基化的变化是研究最多的表观遗传机制之一，被认为是早期癌症检测的初始标记。我们评估了参与一碳代谢的饮食因素（叶酸和维生素B12）的可用性如何有助于人类受试者癌症相关基因的DNA甲基化变化。

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期刊名称 Clinical Epigenetics
作者
Hugo Sanchez; Mohammad B. Hossain; Lydia Lera; Sandra Hirsch; Cecilia Albala; Ricardo Uauy; Karin Broberg; Ana M. Ronco;
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作者单位

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年(卷),期 2017(9),-1
年度 2017
页码 74
总页数 11
原文格式 PDF
正文语种
中图分类遗传学;
关键词
Folates DNA methylation Tumor suppressor genes;

机译：叶酸;DNA甲基化;抑癌基因;

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专利

1. Increased methylation of tumor suppressor genes p16, MLH1 and MGMT in elderly with high serum folate concentrations [J] . Maria Ronco Ana, Sanchez Hugo, Lera Lydia, International journal of molecular medicine . 2016,第Suppla1期

机译：高血清叶酸浓度的老年人中抑癌基因p16，MLH1和MGMT的甲基化增加
2. Environmental arsenic exposure and DNA methylation of the tumor suppressor gene p16 and the DNA repair gene MLH1: effect of arsenic metabolism and genotype [J] . Hossain Mohammad Bakhtiar, Vahter Marie, Concha Gabriela, Metallomics. integrated biometal science . 2012,第11期

机译：抑癌基因p16和DNA修复基因MLH1的环境砷暴露和DNA甲基化：砷代谢和基因型的影响
3. Tumor Mismatch Repair Immunohistochemistry and DNA MLH1 Methylation Testing of Patients With Endometrial Cancer Diagnosed at Age Younger Than 60 Years Optimizes Triage for Population-Level Germline Mismatch Repair Gene Mutation Testing [J] . Daniel D. Buchanan, Yen Y. Tan, Michael D. Walsh, Journal of Clinical Oncology . 2014,第2期

机译：肿瘤不匹配修复免疫组化和DNA MLH1患者的子宫内膜癌患者诊断为年龄小于60岁，优化了人口水平种系错匹配修复基因突变检测的分类
4. In Situ Analysis of DNA Repair Processes of Tumor Suppressor BRCA1 [C] . Leizhen Wei, Natsuko Chiba International Conference on Biomedical Engineering . 2008

机译：肿瘤抑制剂BRCA1 DNA修复过程的原位分析
5. Resistance of glioblastoma cells to alkylating agents: Role of tumor suppressor p53 and DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT). [D] . Bocangel, Dora Beatriz. 2003

机译：胶质母细胞瘤细胞对烷基化剂的耐药性：抑癌基因p53和DNA修复蛋白O6-甲基鸟嘌呤-DNA-甲基转移酶（MGMT）的作用。
6. Tumor Mismatch Repair Immunohistochemistry and DNA MLH1 Methylation Testing of Patients With Endometrial Cancer Diagnosed at Age Younger Than 60 Years Optimizes Triage for Population-Level Germline Mismatch Repair Gene Mutation Testing [O] . Daniel D. Buchanan, Yen Y. Tan, Michael D. Walsh, -1

机译：年龄小于60岁的子宫内膜癌患者的肿瘤错配修复免疫组织化学和DNA MLH1甲基化测试优化了人群水平种系错配修复基因突变测试的分类。
7. High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans [O] . Sanchez, Hugo, Hossain, Mohammad Bakhtiar, Lera, Lydia, 2017

机译：高水平的循环叶酸浓度与肿瘤抑制因子的DNa甲基化和修复基因p16，mLH1和mGmT在智利老年人有关

High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16 MLH1 and MGMT in elderly Chileans

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