Overexpressed Claudin-1 Can Be Visualized Endoscopically in Colonic Adenomas In Vivo

机译：过表达的Claudin-1可以在内窥镜下在体内的结肠腺瘤中可视化

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Background & AimsConventional white-light colonoscopy aims to reduce the incidence and mortality of colorectal cancer (CRC). CRC has been found to arise from missed polypoid and flat precancerous lesions. We aimed to establish proof-of-concept for real-time endoscopic imaging of colonic adenomas using a near-infrared peptide that is specific for claudin-1.

机译：背景与目的常规白光结肠镜检查旨在降低结直肠癌（CRC）的发病率和死亡率。已发现CRC是由息肉样息肉和平坦的癌前病变遗漏引起的。我们的目标是使用对claudin-1具有特异性的近红外肽建立结肠腺瘤实时内窥镜成像的概念验证。

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期刊名称 Cellular and Molecular Gastroenterology and Hepatology
作者
Emily F. Rabinsky; Bishnu P. Joshi; Asha Pant; Juan Zhou; Xiyu Duan; Arlene Smith; Rork Kuick; Shuling Fan; Asma Nusrat; Scott R. Owens; Henry D. Appelman; Thomas D. Wang;
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年(卷),期 2016(2),2
年度 2016
页码 222–237
总页数 16
原文格式 PDF
正文语种
中图分类免疫学;
关键词
Colon Cancer Early Detection Molecular Imaging;

机译：结肠癌;早期发现;分子成像;

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专利

1. Ampullary adenocarcinoma is the most frequent malignant tumour of the small bowel and Vaterian adenoma represents 14 to 20% of benign tumours of the small bowel. Endoscopic ampullectomy concerns adenomas or even adenocarcinomas if they are strictly intramucosal [1]. Adenocarcinomas and adenomas represent 50% and 30%, respectively, of ampullary tumours. The adenoma-cancer relation with a picture of colonic carcinogenesis seems to be established for this type of tumour. There is no known epidemiol [J] . Journal of Clinical Immunology . 2009,第5期

机译：壶腹腺癌是小肠最常见的恶性肿瘤，而Vaterian腺瘤占小肠良性肿瘤的14％至20％。内镜下壶腹切除术如果严格地在粘膜内，则可能涉及腺瘤甚至腺癌[1]。腺癌和腺瘤分别占壶腹肿瘤的50％和30％。对于这种类型的肿瘤，似乎已经建立了与结肠癌发生有关的腺瘤-癌症关系。没有已知的流行病
2. Long-term adenoma recurrence following wide-field endoscopic mucosal resection (WF-EMR) for advanced colonic mucosal neoplasia is infrequent: results and risk factors in 1000 cases from the Australian Colonic EMR (ACE) study [J] . Moss Alan, Williams Stephen J., Hourigan Luke F., Gut: Journal of the British Society of Gastroenterology . 2015,第1期

机译：广谱内镜下黏膜切除术（WF-EMR）对于晚期结肠粘膜瘤形成的长期腺瘤复发很少见：澳大利亚结肠EMR（ACE）研究的1000例结果和危险因素
3. Laparoscopic-Facilitated Colonic Endoscopic Mucosal Resection and Endoscopic Submucosal Resection of Adenomas: Techniques to Avoid Segmental Colectomy [J] . Journal of Gastrointestinal Surgery . 2011,第8期

机译：腹腔镜促进结肠内镜黏膜切除术和内镜黏膜下切除腺瘤：避免节段性结肠切除术的技术
4. Real-time in-vivo endoscopic imaging of fluorescence from human colonic adenomas [C] . Thomas D. Wang, Harvard Medical School, Massachusetts Institute of Technology, Conference on systems and technologies for clinical diagnostics and drug discovery . 1998

机译：实时结肠内镜下人结肠腺瘤的荧光成像
5. Identification of the soluble granulocyte-macrophage colony stimulating factor receptor protein in vivo and development of a soluble model of the high-affinity cell surface receptor for granulocyte-macrophage colony stimulating factor [D] . Prevost, Jay Michael 1999

机译：体内可溶性粒细胞-巨噬细胞集落刺激因子受体蛋白的鉴定和粒细胞-巨噬细胞集落刺激因子高亲和力细胞表面受体可溶性模型的建立
6. EGFR Overexpressed in Colonic Neoplasia Can be Detected on Wide-Field Endoscopic Imaging [O] . Juan Zhou, Bishnu P Joshi, Xiyu Duan, 2015

机译：广谱内窥镜成像可以检测到在结肠肿瘤中过度表达的EGFR
7. Overexpressed Claudin-1 Can Be Visualized Endoscopically in Colonic Adenomas In Vivo [O] . Rabinsky Emily F., Joshi Bishnu P., Pant Asha, 2016

机译：过表达的Claudin-1可以在内窥镜下在体内的结肠腺瘤中可视化

Overexpressed Claudin-1 Can Be Visualized Endoscopically in Colonic Adenomas In Vivo

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