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Immunocytochemical localization of the ovine immunoglobulins IgA IgG1 IgG1A and IgG2: effect of gastro-intestinal parasitism in the sheep

机译:绵羊免疫球蛋白IgAIgG1IgG1A和IgG2的免疫细胞化学定位:绵羊肠胃寄生虫的作用

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摘要

A study has been made of the immunocytochemical localization of IgG1, IgG2, IgG1A and IgA in the alimentary tract and associated lymph nodes of parasitized and parasite-free sheep. No immunoglobulin-containing cells were found in the abomasal mucosa of the parasite-free sheep. On the other hand, large numbers of IgG1 and IgG1A-containing cells were found in the lamina propria and at the base of the villi of the abomasum of the parasitized sheep. IgG1, IgG1A, and IgA-containing cells were found in mucosal sections from the jejunum and ileum of both parasitized and parasite-free sheep, the number of IgG1A-containing cells being sifnificantly greater in the former than in the latter. This increase was considered to be of some importance since the IgG1A subclass appears to be involved in the allergic response of the sheep to intestinal parasites.
机译:IgG1,IgG2,IgG1A和IgA在寄生虫和无寄生虫的绵羊的消化道和相关淋巴结中的免疫细胞化学定位研究已经完成。在无寄生虫的绵羊的腹膜粘膜中未发现含免疫球蛋白的细胞。另一方面,在被寄生的绵羊的固有层和绒毛底部的绒毛底部发现了大量含有IgG1和IgG1A的细胞。在寄生和无寄生绵羊的空肠和回肠的粘膜切片中均发现了含IgG1,IgG1A和IgA的细胞,前者中含IgG1A的细胞明显多于后者。由于IgG1A亚类似乎与绵羊对肠道寄生虫的过敏反应有关,因此认为这种增加具有一定的重要性。

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