Pre- and postnatal administration of Lactobacillus reuteri decreases TLR2 responses in infants

摘要

BackgroundMice models indicate that intact Toll like receptor (TLR) signaling may be essential for the allergy protective effects of diverse bacterial exposure observed in clinical trials and epidemiological studies. Probiotic supplementation with Lactobacillus reuteri from pregnancy week 36 and to the infant through the first year of life decreased the prevalence of IgE-associated eczema at two years (ClinicalTrials.gov ). The effect of this supplementation on innate immune responses to bacterial products and the expression of associated TLRs were explored.