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Results of a phase I/II clinical trial: standardized non-xenogenic cultivated limbal stem cell transplantation

机译：I / II期临床试验的结果：标准化非异种培养的角膜缘干细胞移植

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摘要

BackgroundTo determine if a standardized, non-xenogenic, reduced manipulation cultivation and surgical transplantation of limbal stem cell grafts is a safe and effective treatment option for patients with total and partial limbal stem cell deficiency.

机译：背景技术确定标准的，非异种的，减少操作的培养和角膜缘干细胞移植的手术移植是否是对全部和部分角膜缘干细胞缺乏症患者的安全有效的治疗选择。

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期刊名称 Journal of Translational Medicine
作者
Nadia Zakaria; Tine Possemiers; Sorcha Ní Dhubhghaill; Inge Leysen; Jos Rozema; Carina Koppen; Jean-Pierre Timmermans; Zwi Berneman; Marie-Jose Tassignon;
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年(卷),期 2014(12),-1
年度 2014
页码 58
总页数 13
原文格式 PDF
正文语种
中图分类医学史 ;
关键词
Limbal stem cell transplantation Clinical trial Amniotic membrane Tissue specific stem cells Tissue regeneration Cell transplantation Cellular therapy Cell culture Progenitor cells Somatic stem cells Limbal epithelial stem cells Corneal reconstruction Ocular surface reconstruction Corneal neovascularization Corneal opacity SHEM CNT-20 Composite grafts;

机译：角膜缘干细胞移植;临床试验;羊膜;组织特异性干细胞;组织再生;细胞移植;细胞疗法;细胞培养;祖细胞;体细胞干细胞;角膜缘上皮干细胞;角膜重建;眼表重建;角膜新生血管形成;角膜混浊;SHEM;CNT-20;复合移植物;

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专利

1. Regeneration of the anterior cornea through a standardized, non-xenogenic, cultivated limbal stem cell transplantation: Results of a phase II clinical trial. [J] . Behaegel Josephine, Koppen Carina, Dhubhghaill Sorcha Ni, Investigative ophthalmology & visual science . 2018 ,第9期

机译：通过标准化的非异叶植物植物干细胞移植进行前角膜的再生：II期临床试验的结果。
2. Regeneration of the anterior cornea through a standardized, non-xenogenic, cultivated limbal stem cell transplantation: Results of a phase II clinical trial. [J] . Behaegel Josephine, Koppen Carina, Dhubhghaill Sorcha Ni, Investigative ophthalmology & visual science . 2018 ,第9期

机译：通过标准化的非异叶植物植物干细胞移植进行前角膜的再生：II期临床试验的结果。
3. Results of a phase I/II clinical trial: standardized, non-xenogenic, cultivated limbal stem cell transplantation [J] . Nadia Zakaria, Tine Possemiers, Sorcha N Dhubhghaill, Journal of Translational Medicine . 2014 ,第1期

机译：I / II期临床试验的结果：标准化，非异种，培养的角膜缘干细胞移植
4. A clinical trial of prophylactic antifungal therapy in patients undergoing hematopoietic stem cell transplantation [C] . Zhou Qi, Lou Fangding, Zhang Bolong Proceedings of the Fourth China-Jpan international congress of mycology . 1998

机译：造血干细胞移植患者预防性抗真菌治疗的临床试验
5. Clinical predictive value of pre-clinical cancer models: A study of the predictive value of the in vitro cell line, human xenograft and murine allograft pre-clinical cancer models for phase II clinical trials of cytotoxic cancer drugs [D] . Voskoglou-Nomikos, Theodora 2001

机译：临床前癌症模型的临床预测价值：体外细胞系，人异种移植和小鼠同种异体移植临床前癌症模型对细胞毒性癌症药物II期临床试验的预测价值研究
6. A Phase II Trial of Autologous Transplantation of Bone Marrow Stem Cells for Critical Limb Ischemia: Results of the Naples and Pietra Ligure Evaluation of Stem Cells Study [O] . Alessandro Schiavetta, Ciro Maione, Chiara Botti, 2012

机译：骨髓干细胞自体移植治疗严重肢体缺血的II期试验：那不勒斯和彼得拉利古雷评价干细胞的研究结果
7. Results of a phase I/II clinical trial: standardized, non-xenogenic, cultivated limbal stem cell transplantation [O] . Nadia Zakaria, Tine Possemiers, Sorcha Dhubhghaill, 2014

机译：I / II期临床试验的结果：标准化，非异种，培养的角膜缘干细胞移植

Results of a phase I/II clinical trial: standardized non-xenogenic cultivated limbal stem cell transplantation

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