Circulating retinol binding protein 4 in critically ill patients before specific treatment: prognostic impact and correlation with organ function metabolism and inflammation

摘要

IntroductionHyperglycemia and insulin resistance are well-known features of critical illness and impact the mortality rate, especially in sepsis. Retinol binding protein 4 (RBP4) promotes insulin resistance in mice and is systemically elevated in patients with obesity and type 2 diabetes. We investigated the potential role of RBP4 in critically ill patients.