METHODS OF IDENTIFYING CRITICALLY ILL PATIENTS AT INCREASED RISK OF DEVELOPMENT OF ORGAN FAILURE AND COMPOUNDS FOR THE TREATMENT HEREOF

摘要

The present invention relates to compounds for treatment that protects theendothelium, prevent pathologic thrombusformation in the microcirculation and preserve platelet number and functionand thus may be related to minimizing or preventingdevelopment of organ failure, including multiple organ failure (MOF), and,hence, death in critically ill patients by administrationof agent(s) limiting the platelets ability to aggregate and form clots and/orby agents modulating/preserving endothelialintegrity and/or by agent(s) increasing the rate of thrombus lysis, andAnother aspect of the invention related to by a cell-basedwhole blood viscoelastical haemostatic assay identifying critically illpatients at increased risk of development of organ failure, includingmultiple organ failure (MOF) and death.