首页> 美国卫生研究院文献>Journal of Zhejiang University. Science. B >A meta-analysis of association between acne ulgaris and Demodex infestation
【2h】

A meta-analysis of association between acne ulgaris and Demodex infestation

机译:寻常痤疮与蠕形螨感染之间关联的Meta分析

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

Until now, etiology of acne vulgaris is still uncertain. Although clinicians usually deny the association between Demodex infestation and acne vulgaris, it has been proved in some clinical practices. To confirm the association between Demodex infestation and acne vulgaris, a meta-analysis was conducted. Predefined selection criteria were applied to search all published papers that analyzed the association between Demodex infestation and acne vulgaris (January 1950 to August 2011) in ISI Web of Knowledge, MEDLINE, and China National Knowledge Infrastructure (CNKI) databases. A meta-analysis was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) based on fixed effects models or random effects models. We enrolled the 60 Chinese and 3 English papers in this meta-analysis, which covered Turkey and 25 different provinces/municipalities in China and 42 130 participants including students and residents, aged from 1 to 78 years. The pooled OR in random effects models is 2.80 (95% CI, 2.34–3.36). Stability is robust according to sensitivity analysis. The fail-safe number is 18 477, suggesting that at least 18 477 articles with negative conclusions would be needed to reverse the conclusion that acne vulgaris was related to Demodex infestation. So the effect of publication bias was insignificant and could be ignored. It was concluded that acne vulgaris is associated with Demodex infestation. This indicates that when regular treatments for acne vulgaris are ineffective, examination of Demodex mites and necessary acaricidal therapies should be considered.
机译:到目前为止,寻常痤疮的病因仍不确定。尽管临床医生通常否认蠕形螨病与寻常性痤疮之间的联系,但已在一些临床实践中证明了这一点。为了证实蠕形螨病和寻常痤疮之间的关联,进行了荟萃分析。在ISI Web of Knowledge,MEDLINE和中国国家知识基础设施(CNKI)数据库中,使用预定义的选择标准来搜索所有分析蠕形螨感染与寻常性痤疮(1950年1月至2011年8月)之间关联的所有已发表论文。进行了荟萃分析,以基于固定效应模型或随机效应模型计算比值比(OR)和95%置信区间(CI)。我们在这项荟萃分析中纳入了60篇中文和3篇英文论文,这些论文涵盖了土耳其和中国的25个不同省/市,以及42 130名参与者,包括年龄在1至78岁之间的学生和居民。随机效应模型中的合并OR为2.80(95%CI,2.34-3.36)。根据敏感性分析,稳定性很强。故障安全数字为18 477,这表明至少需要18 477篇带有负面结论的文章才能扭转寻常痤疮与蠕形螨病相关的结论。因此,出版偏差的影响微不足道,可以忽略不计。结论是寻常痤疮与蠕形螨病侵染有关。这表明当常规治疗痤疮无效时,应考虑对蠕形螨的检查和必要的杀螨疗法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号