Allergic Models of Inflammation: 27 Serine Protease Inhibitor Attenuates Ova Induced Inflammation in Mouse Model of Allergic Airway Disease

摘要

BackgroundSerine proteases promote inflammation and tissue remodeling by activating proteinase-activated receptors, urokinase, metalloproteinases and angiotensin. In the present study, AEBSF (4-(2-Aminoethyl) benzenesulfonyl fluoride) a serine protease inhibitor, was evaluated for prophylactic and therapeutic treatment in mouse model of airway allergy.