P25. In vitro evaluation of the anticancer activity of ganetespib in combination with standard chemotherapeutics in small cell lung cancer (SCLC) cell lines

摘要

BackgroundGanetespib (STA-9090) has anticancer activity due to inhibition of the chaperoning activity of HSP90 for oncogenes and other cellular proteins which support malignant growth. Especially, clinical activity as single drug was found in tumors addicted to modified kinases, such as HER2, ALK, BRAF, KIT and others. In the present work we tested the cytotoxic effects of ganetespib either alone or in combination with chemotherapeutics against a panel of small cell lung cancer cell lines.