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Skeletal muscle-derived interstitial progenitor cells (PICs) display stem cell properties being clonogenic self-renewing and multi-potent in vitro and in vivo

机译：骨骼肌源性间质祖细胞（PIC）显示干细胞特性在体外和体内具有克隆性自我更新和多能性

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BackgroundThe development of cellular therapies to treat muscle wastage with disease or age is paramount. Resident muscle satellite cells are not currently regarded as a viable cell source due to their limited migration and growth capability ex vivo. This study investigated the potential of muscle-derived PW1⁺/Pax7^– interstitial progenitor cells (PICs) as a source of tissue-specific stem/progenitor cells with stem cell properties and multipotency.

机译：背景技术开发治疗疾病或年龄引起的肌肉浪费的细胞疗法至关重要。由于它们的离体迁移和生长能力有限，因此常驻肌卫星细胞目前不被视为活细胞来源。这项研究调查了肌肉来源的PW1 ^{+ / Pax7 ^{– 间质祖细胞（PICs）作为组织特异性干/祖细胞来源的潜力，这些干细胞具有干细胞特性和多能。}}

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期刊名称 Stem Cell Research Therapy
作者
Beverley J. Cottle; Fiona C. Lewis; Victoria Shone; Georgina M. Ellison-Hughes;
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作者单位

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年(卷),期 2017(8),-1
年度 2017
页码 158
总页数 16
原文格式 PDF
正文语种
中图分类细胞生物学;医学史;
关键词
PIC PW1 Sca-1 Muscle-derived Stem progenitor cell Multipotent Clonogenic Cell culture;

机译：PIC;PW1;Sca-1;肌肉来源的干祖细胞;专能;克隆性;细胞培养;

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专利

1. Skeletal muscle-derived interstitial progenitor cells (PICs) display stem cell properties, being clonogenic, self-renewing, and multi-potent in vitro and in vivo [J] . Beverley J. Cottle, Fiona C. Lewis, Victoria Shone, Stem Cell Research & Therapy . 2017,第1期

机译：骨骼肌源性间质祖细胞（PIC）显示干细胞特性，在体外和体内具有克隆性，自我更新和多能性
2. Human Neural Stem and Progenitor Cells: In Vitro and In Vivo Properties, and Potential for Gene Therapy and Cell Replacement in the CNS [J] . Alberto Martinez-serrano F. Javier Rubio Beatriz Navarro Carlos Bueno Ana Villa Current Gene Therapy . 2001,第3期

机译：人类神经干细胞和祖细胞：体外和体内特性，以及中枢神经系统中基因治疗和细胞置换的潜力
3. Human Hepatocytes and Differentiated Adult-Derived Human Liver Stem/Progenitor Cells Display In Vitro Immunosuppressive Properties Mediated, at Least in Part, through the Nonclassical HLA Class I Molecule HLA-G [J] . Catherine A. Lombard, Gwena?lle Sana, Jo?l LeMaoult, Journal of immunology research. . 2019,第1期

机译：人肝细胞和分化的成人衍生的人肝茎/祖细胞至少部分地通过非分类HLA I类分子HLA-G介导体外免疫抑制性能
4. Cardiomyogenic Potential of Skeletal Muscle-Derived Progenitor Cells [C] . C. Poulet International Society for Heart Research . 2008

机译：骨骼肌衍生祖细胞的心肌膜潜力
5. Maintaining the self-renewal and multipotential capacity of human mesenchymal stem/progenitor cells (MSCS) from bone marrow stroma in vitro to ensure efficacy in vivo. [D] . Larson, Benjamin Lee. 2009

机译：体外维持来自骨髓基质的人间充质干/祖细胞（MSCS）的自我更新和多能能力，以确保体内功效。
6. Human Hepatocytes and Differentiated Adult-Derived Human Liver Stem/Progenitor Cells Display In Vitro Immunosuppressive Properties Mediated at Least in Part through the Nonclassical HLA Class I Molecule HLA-G [O] . Catherine A. Lombard, Gwenaëlle Sana, Joël LeMaoult, 2019

机译：人肝细胞和分化的成年成人肝干/祖细胞显示出通过非经典HLA I类分子HLA-G介导的体外免疫抑制特性
7. Skeletal muscle-derived interstitial progenitor cells (PICs) display stem cell properties, being clonogenic, self-renewing, and multi-potent in vitro and in vivo [O] . Cottle, Beverley J., Lewis, Fiona C., Shone, Victoria, 2017

机译：骨骼肌源性间质祖细胞（PIC）显示干细胞特性，在体外和体内具有克隆性，自我更新和多能性

Skeletal muscle-derived interstitial progenitor cells (PICs) display stem cell properties being clonogenic self-renewing and multi-potent in vitro and in vivo

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