Background. Few data are available on quarterly 11.25 mg GnRH analog treatment in central precocious puberty (CPP). Aim. To assess the efficacy of triptorelin 11.25 mg in children with CPP. Patients. 17 patients (16 females) with CPP (7.9 ± 0.9 years) were treated with triptorelin 11.25 mg/90 days. Methods. Gonadotropins, basal-, and GnRH-stimulated peak, gonadal steroids, and pubertal signs were assessed at preinclusion and at inclusion visit, 3 months, 6 months, and 12 months of treatment. Results. At 3, 6, and 12 months, all patients had suppressed LH peak (<3 IU/L after GnRH stimulation), as well as prepubertal oestradiol levels. Mean LH peak values after GnRH test significantly decreased from 25.7 ± 16.5 IU/L at baseline to 0.9 ± 0.5 IU/L at M3 (P < 0.0001); they did not significantly changed at M6 and M12. Conclusions. Triptorelin 11.25 mg/90 days efficiently suppressed the pituitary-gonadal axis in children with CPP from first administration.
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机译：背景。在中枢性性早熟（CPP）中，每季11.25mg GnRH类似物治疗的数据很少。目标。评估曲普瑞林11.25mg在CPP儿童中的疗效。耐心。接受曲普瑞林11.25 mg / 90天治疗17例CPP（7.9±0.9岁）的患者（16名女性）。方法。在治疗前和入选时，治疗3个月，6个月和12个月时评估了促性腺激素，基底刺激和GnRH刺激的高峰，性腺类固醇和青春期体征。结果。在第3、6和12个月时，所有患者的LH峰值（GnRH刺激后<3 IU / L）均得到抑制，青春期前雌二醇水平也得到抑制。 GnRH试验后的平均LH峰值从基线时的25.7±16.5 IU / L显着降低至M3时的0.9±0.5 IU / L（P <0.0001）；在M6和M12时，它们没有明显变化。结论。雷公藤甲素11.25 mg / 90天可有效抑制CPP患儿的垂体-性腺轴。
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