Single nucleotide polymorphism marker for diagnosing precocious puberty or prognosising treatment of precocious puberty and use thereof

摘要

The present invention relates to a single nucleotide polymorphism marker for diagnosing precocious puberty or predicting the prognosis of treatment, and a use thereof.In the present invention, the DNA of 700 precocious girls patients is processed on a microarray chip containing a total of 8,754,887 SNP probes to obtain SNP genotyping data. And 23 SNPs associated with the risk of precocious puberty were discovered through full-length genetic association analysis.The SNP can be used to diagnose precocious puberty or predict the prognosis of treatment, and it is possible to easily and quickly diagnose precocious puberty, and treatment effect and prognosis. It is possible to predict about and can be usefully used for personalized treatment.