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Humanized anti CCR4 antibody KW0761 targets HTLV-1 infected CD4+ CCR4+ and CD8+CCR4+ T cells to treat HAM/TSP

机译：人源化抗CCR4抗体KW0761靶向HTLV-1感染的CD4 + CCR4 +和CD8 + CCR4 + T细胞以治疗HAM / TSP

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期刊名称 Retrovirology
作者
Yoshihisa Yamano; Junji Yamauchi; Ariella Coler-Reilly; Tomoo Sato; Natsumi Araya; Naoko Yagishita; Yasuo Kunitomo; Katsunori Takahashi; Yuetsu Tanaka; Hisanao Akiyama; Yasuhiro Hasegawa; Atae Utsunomiya;
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年(卷),期 2015(12),Suppl 1
年度 2015
页码 O23
总页数 1
原文格式 PDF
正文语种
中图分类人体病毒学（致病病毒）;病毒（滤过性病毒）;
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1. Humanized anti CCR4 antibody KW0761 targets HTLV-1 infected CD4+ CCR4+ and CD8+CCR4+ T cells to treat HAM/TSP [J] . Yoshihisa Yamano, Junji Yamauchi, Ariella Coler-Reilly, Retrovirology . 2015,第S1期

机译：人源化抗CCR4抗体KW0761靶向HTLV-1感染的CD4 + CCR4 +和CD8 + CCR4 + T细胞，以治疗HAM / TSP
2. T CD4+ cells count among patients co-infected with human immunodeficiency virus type 1 (HIV-1) and human T-cell leukemia virus type 1 (HTLV-1): high prevalence of tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM) [J] . Alberto José Da Silva Duarte, Augusto Cesar Penalva De Oliveira, Ingrid Olah, Revista do Instituto de Medicina Tropical de So Paulo . 2007,第4期

机译：合并感染1型人类免疫缺陷病毒（HIV-1）和1型人类T细胞白血病病毒（HTLV-1）的患者中T CD4 +细胞计数：热带痉挛性轻瘫/ HTLV-1相关性脊髓病（TSP）患病率高/火腿）
3. HTLV-1 induces a Th1-like state in CD4(+) CCR4(+) T cells that produces an inflammatory positive feedback loop via astrocytes in HAM/TSP [J] . Yamano Yoshihisa, Coler-Reilly Ariella Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2017,第期

机译：HTLV-1在CD4（+）CCR4（+）T细胞中诱导TH1样状态，其通过火腿/ TSP的星形胶质细胞产生炎性阳性反馈回路
4. Measurement of Fc-Mediated ADCC and CDC Activity of Anti-TNFα and Anti-VEGF Therapeutic Antibodies Using Reporter-Based Bioassays and Engineered TNFα+ and VEGF+ Target Cells [C] . Hetal Marble, Denise Garvin, Jamison Grailer, Protein Engineering Summit. . 2018

机译：使用基于报道的生物测定和工程化TNFα+和VEGF +靶细胞测量抗TNFα和抗VEGF治疗抗体的FC介导的ADCC和CDC活性的测量
5. Targeted delivery of immunoliposomal doxorubicin to B-lymphoid cells via an anti-CD19 whole monoclonal antibody or fragments of antibody. [D] . Cheng, Wilson Wan Kin. 2008

机译：通过抗CD19完整单克隆抗体或抗体片段将免疫脂质体阿霉素靶向递送至B淋巴样细胞。
6. Clinical trial of a humanized monoclonal anti-IL15Rβ (CD122) in HTLV-1 associated myelopathy/ tropical spastic paraparesis (HAM/TSP) [O] . Raya Massoud, Yoshimi Enose-Akahata, Giovanna S Brunetto, 2014

机译：人源化单克隆抗IL15Rβ（CD122）在HTLV-1相关性脊髓病/热带痉挛性轻瘫（HAM / TSP）中的临床试验
7. T CD4+ cells count among patients co-infected with human immunodeficiency virus type 1 (HIV-1) and human T-cell leukemia virus type 1 (HTLV-1): high prevalence of tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM) Contagens de células T CD4+ na co-infecção HIV-1 e HTLV-1: alta prevalência da paraparesia espástica tropical/mielopatia associada ao HTLV-1 [O] . Jorge Casseb, Maria Paulina Posada-Vergara, Patrícia Montanheiro, 2007

机译：共感染1型人类免疫缺陷病毒（HIV-1）和人类T细胞白血病病毒1型（HTLV-1）的患者中T CD4 +细胞计数：热带痉挛性下肢瘫痪/ HTLV-1相关性脊髓病（Tsp）患病率高/ Ham）ContagensdecélulasTCD4 + na co-infecçãoHIV-1 e HTLV-1：altaprevalênciadaparaparesiaespásticactropical/ mielopatia associada ao HTLV-1

Humanized anti CCR4 antibody KW0761 targets HTLV-1 infected CD4+ CCR4+ and CD8+CCR4+ T cells to treat HAM/TSP

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