Role of the ion channel transient receptor potential cation channel subfamily V member 1 (TRPV1) in allergic asthma

摘要

BackgroundAsthma prevalence has increased world-wide especially in children; thus there is a need to develop new therapies that are safe and effective especially for patients with severe/refractory asthma. CD4⁺ T cells are thought to play a central role in disease pathogenesis and associated symptoms. Recently, TRPV1 has been demonstrated to regulate the activation and inflammatory properties of CD4⁺ cells. The aim of these experiments was to demonstrate the importance of CD4⁺ T cells and the role of TRPV1 in an asthma model using a clinically ready TRPV1 inhibitor (XEN-D0501) and genetically modified (GM) animals.