We have micromachined a silicon-chip device that transports DNA with a Brownian ratchet that rectifies the Brownian motion of microscopic particles. Transport properties for a DNA 50-mer agree with theoretical predictions, and the DNA diffusion constant agrees with previous experiments. This type of micromachine could provide a generic pump or separation component for DNA or other charged species as part of a microscale lab-on-a-chip. A device with reduced feature size could produce a size-based separation of DNA molecules, with applications including the detection of single-nucleotide polymorphisms.
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机译：我们已经对硅芯片设备进行了微加工，该设备使用布朗棘轮来传输DNA，该棘轮纠正了微观粒子的布朗运动。 DNA 50聚体的转运特性与理论预测相符，DNA扩散常数与先前的实验相符。这种类型的微型计算机可以为DNA或其他带电物种提供通用泵或分离组件，作为微型芯片实验室的一部分。具有减小的特征尺寸的设备可以产生基于尺寸的DNA分子分离，其应用包括检测单核苷酸多态性。
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