Plasma group I pepsinogen (PG I) concentration is now a readily available non-invasive marker of gastric secretory function, with several potentially useful applications. Ninety-eight percent of control subjects had a plasma PG I below 115 ng/ml while values above this level were seen in 43% of duodenal ulcer patients. Plasma PG I levels below the observed normal lower limit of 30 ng/ml were seen consistently in patients with documented achlorhydria or pernicious anaemia. In 48 patients with a variety of upper gastrointestinal disorders there was a significant correlation between PG I pepsinogens and pentagastrin-stimulated maximal acid output. Changes in plasma PG I promise to be useful in evaluating both operations on the vagus and newer anticholinergic drugs, whilst in epidemiological and family studies these measurements seem well suited to explore duodenal ulcer heterogeneity.
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机译：现在，血浆I组胃蛋白酶原（PG I）浓度是一种容易获得的胃分泌功能的非侵入性标记物，具有多种潜在有用的应用。 98％的对照受试者的血浆PG I低于115 ng / ml，而在43％的十二指肠溃疡患者中发现该值高于该水平。在有胃酸缺乏症或恶性贫血的患者中，血浆PG I水平始终低于观察到的正常下限30 ng / ml。在48位患有各种上消化道疾病的患者中，PG I胃蛋白酶原与五肽胃泌素刺激的最大酸输出量之间存在显着相关性。血浆PG I的变化有望对评估迷走神经和新的抗胆碱能药物的操作均有用，而在流行病学和家庭研究中，这些测量值似乎非常适合探索十二指肠溃疡的异质性。
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