首页> 美国卫生研究院文献>Polymers >Electrospun Poly(lactide-co-glycolide-co-3(S)-methyl-morpholine-25-dione) Nanofibrous Scaffolds for Tissue Engineering
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Electrospun Poly(lactide-co-glycolide-co-3(S)-methyl-morpholine-25-dione) Nanofibrous Scaffolds for Tissue Engineering

机译:用于组织工程的电纺聚(丙交酯-乙交酯-co-3(S)-甲基吗啉-25-二酮)纳米纤维支架。

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摘要

Biomimetic scaffolds have been investigated in vascular tissue engineering for many years. Excellent biodegradable materials are desired as temporary scaffolds to support cell growth and disappear gradually with the progress of guided tissue regeneration. In the present paper, a series of biodegradable copolymers were synthesized and used to prepared microanofibrous scaffolds for vascular tissue engineering. Poly(lactide-co-glycolide-co-3(S)-methyl-morpholine-2,5-dione) [P(LA-co-GA-co-MMD)] copolymers with different l-lactide (LA), glycolide (GA), and 3(S)-methyl-2,5-morpholinedione (MMD) contents were synthesized using stannous octoate as a catalyst. Moreover, the P(LA-co-GA-co-MMD) nanofibrous scaffolds were prepared by electrospinning technology. The morphology of scaffolds was analyzed by scanning electron microscopy (SEM), and the results showed that the fibers are smooth, regular, and randomly oriented with diameters of 700 ± 100 nm. The weight loss of scaffolds increased significantly with the increasing content of MMD, indicating good biodegradable property of the scaffolds. In addition, the cytocompatibility of electrospun nanofibrous scaffolds was tested by human umbilical vein endothelial cells. It is demonstrated that the cells could attach and proliferate well on P(LA-co-GA-co-MMD) scaffolds and, consequently, form a cell monolayer fully covering on the scaffold surface. Furthermore, the P(LA-co-GA-co-MMD) scaffolds benefit to excellent cell infiltration after subcutaneous implantation. These results indicated that the P(LA-co-GA-co-MMD) nanofibrous scaffolds could be potential candidates for vascular tissue engineering.
机译:仿生支架已经在血管组织工程中进行了多年研究。理想的生物可降解材料是用作支架的临时支架,以支持细胞生长并随着引导的组织再生的进行而逐渐消失。本文合成了一系列可生物降解的共聚物,并用于制备用于血管组织工程的微/纳米纤维支架。聚(丙交酯-乙交酯-co-3(S)-甲基吗啉-2,5-二酮)[P(LA-co-GA-co-MMD)]共聚物,带有不同的l-丙交酯(LA),乙交酯(GA)和3(S)-甲基-2,5-吗啉代二酮(MMD)含量以辛酸亚锡为催化剂合成。此外,通过静电纺丝技术制备了P(LA-co-GA-co-MMD)纳米纤维支架。通过扫描电子显微镜(SEM)分析了支架的形态,结果表明纤维是光滑的,规则的和无规取向的,直径为700±100nm。支架的重量损失随着MMD含量的增加而显着增加,表明支架具有良好的生物降解性能。另外,通过人脐静脉内皮细胞测试了电纺纳米纤维支架的细胞相容性。已证明细胞可以在P(LA-co-GA-co-MMD)支架上附着并良好增殖,从而形成完全覆盖在支架表面的细胞单层。此外,P(LA-co-GA-co-MMD)支架有利于皮下植入后优异的细胞浸润。这些结果表明,P(LA-co-GA-co-MMD)纳米纤维支架可能是血管组织工程的潜在候选者。

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