Electrospun silk fibroin blend nanofibrous scaffold and its use in tissue engineering

摘要

The present invention discloses a novel silk biomaterial blend and its fabrication to non-oven network of electrospun nanofibrous 3D mat. The prepared nanofibers comprise of silk fibroin proteins that are derived from two varieties of locally grown silks i.e. Eri (Phylisomia ricini) and Tasar (Antheraea mylitta). The two varieties of silks were selected to prepare nanofibers that have the characteristics of both to meet the desired properties of tissue engineering scaffold. The nanofibrous mat can be used as scaffold to develop tissue constructs by seeding mammalian cells and other tissues for various tissue engineering applications based on the mechanical, cell adhesion, and cell proliferation of the cell-seeded fibrous structure.