Phase I/II clinical trial of the targeted chemotherapeutic drug folate-tubulysin in dogs with naturally-occurring invasive urothelial carcinoma

摘要

PurposeThe purpose was to determine the safety and antitumor activity of a folate-tubulysin conjugate (EC0531) in a relevant preclinical animal model, dogs with naturally-occurring invasive urothelial carcinoma (iUC). Canine iUC is an aggressive cancer with high folate receptor (FR) expression similar to that in certain forms of human cancer.