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Keratin 18-deficiency results in steatohepatitis and liver tumors in old mice: A model of steatohepatitis-associated liver carcinogenesis

机译：角蛋白18缺乏导致老年小鼠脂肪性肝炎和肝肿瘤：与脂肪性肝炎相关的肝癌发生模型

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BackroundSteatohepatitis (SH)-associated liver carcinogenesis is an increasingly important issue in clinical medicine. SH is morphologically characterized by steatosis, hepatocyte injury, ballooning, hepatocytic cytoplasmic inclusions termed Mallory-Denk bodies (MDBs), inflammation and fibrosis.

机译：背景硬脂性肝炎（SH）相关的肝癌发生在临床医学中日益重要。 SH的形态学特征为脂肪变性，肝细胞损伤，膨胀，被称为Mallory-Denk体（MDB）的肝细胞胞质内含物，炎症和纤维化。

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期刊名称 Oncotarget
作者
Kira Bettermann; Anita Kuldeep Mehta; Eva M. Hofer; Christina Wohlrab; Nicole Golob-Schwarzl; Vendula Svendova; Michael G. Schimek; Cornelia Stumptner; Andrea Thüringer; Michael R. Speicher; Carolin Lackner; Kurt Zatloukal; Helmut Denk; Johannes Haybaeck;
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年(卷),期 2016(7),45
年度 2016
页码 73309–73322
总页数 14
原文格式 PDF
正文语种
中图分类肿瘤学 ; 细胞生物学 ;
关键词
Steatohepatitis Keratin 18 deficiency Liver tumors Mallory-Denk bodies;

机译：脂肪性肝炎;角蛋白18缺乏症;肝肿瘤;马洛里-登克氏体;

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1. The Alisma and Rhizoma decoction abates nonalcoholic steatohepatitis-associated liver injuries in mice by modulating oxidative stress and autophagy [J] . Lijun Xu, Menghui Jing, Lijuan Yang, BMC Complementary and Alternative Medicine . 2019 ,第1期

机译：泽泻和根茎汤可通过调节氧化应激和自噬减轻小鼠非酒精性脂肪性肝炎相关的肝损伤
2. Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat–cholesterol–sugar diet model in mice [J] . Michal Ganz, Terence N Bukong, Timea Csak, Journal of Translational Medicine . 2015 ,第1期

机译：非酒精性脂肪变性向脂肪性肝炎和纤维化的进展与高脂-胆固醇-糖饮食模型中促进炎症和肝肿瘤的危险信号的累积积累相似
3. A Novel Antihepatitis Drug, Bicyclol, Prevents Liver Carcinogenesis in Diethylnitrosamine-Initiated and Phenobarbital-Promoted Mice Tumor Model [J] . HuaSun, LinghongYu, HuailingWei, BioMed research international . 2012 ,第4期

机译：新型抗肝炎药物双环醇可预防二乙基亚硝胺引发和苯巴比妥促进的小鼠肿瘤模型中的肝癌发生
4. Suppression of tumor growth in H-ras liver cancer model mice by programmed cell death 4 gene delivery using galactosylated poly(ethylene glycol)-chitosan-graft-spermine [C] . Hu-Lin Jiang, You-Kyoung Kim, Chong-Su Cho, World biomaterials congress . 2012

机译：半乳糖基化聚乙二醇-壳聚糖-接枝-精胺通过程序性细胞死亡4基因传递抑制H-ras肝癌模型小鼠的肿瘤生长
5. Osteopontin-mediated neutrophilic infiltration and higher liver injury in a female rodent alcoholic steatohepatitis model. [D] . Banerjee, Atrayee. 2008

机译：雌性啮齿动物酒精性脂肪性肝炎模型中骨桥蛋白介导的嗜中性粒细胞浸润和较高的肝损伤。
6. MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis [O] . Aline de Conti, Juliana Festa Ortega, Volodymyr Tryndyak, 2017

机译：在非酒精性脂肪性肝炎相关的肝癌发生中的MicroRNA解除调节
7. Faculty Opinions recommendation of Dipeptidyl peptidase-4 inhibition prevents nonalcoholic steatohepatitis-associated liver fibrosis and tumor development in mice independently of its anti-diabetic effects. [O] . Mark Gorrell 2020

机译：二肽肽酶-4抑制的教师意见建议防止小鼠的非酒精性脂肪磷脂炎相关肝纤维化和肿瘤发育，其抗糖尿病效应。

Keratin 18-deficiency results in steatohepatitis and liver tumors in old mice: A model of steatohepatitis-associated liver carcinogenesis

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