MODEL FOR NASH OR LIVER TUMOR, METHOD FOR PRODUCTION OF THE MODEL, METHOD FOR SCREENING OF THERAPEUTIC AGENT FOR NASH OR LIVER TUMOR, METHOD FOR ANALYSIS OF MECHANISM FOR DEVELOPMENT OF NASH OR LIVER TUMORM, AND AGENT FOR PREVENTION OR TREATMENT OF NASH

摘要

[PROBLEMS] To provide a model animal which can present a symptom distinctive for non-alcoholic steatohepatitis (NASH) within a short period of time without artificially deleting a gene originally expressed in 'a hepatocyte' or a model animal for liver tumor caused by NASH; the elucidation of the mechanism for development of NASH or liver tumor; screening of an agent for the prevention or treatment of NASH or liver tumor; and an agent for the prevention or treatment of NASH. [MEANS FOR SOLVING PROBLEMS] A model animal for non-alcoholic steatohepatitis or liver tumor having a gene encoding a part or the entire of the amino acid sequence for SREBP1c having a transcriptional activity and a promoter gene capable of directing an adipose tissue-specific expression introduced therein; and an agent for preventing or treating NASH, comprising one or more substances selected from adiponectin or an analogue thereof and a gene encoding adiponectin or the analogue thereof as the active ingredient(s).