Naloxegol hydrogen oxalate displaying a hydrogen-bonded layer structure

摘要

In the salt (5α,6α)-6-[(2,5,8,11,14,17,20-hepta­oxadocosan-22-yl)­oxy]-3,14-dihy­droxy-17-(prop-2-en-1-yl)-4,5-ep­oxy­morphinan-17-ium hydrogen oxalate, C34H54NO11 ⁺·C2HO4 ⁻ the polyether unit of the naloxegol cation adopts the shape of a squashed open letter ‘O’. In the crystal, the hydrogen oxalate anions are linked into a chain by O—H⋯O hydrogen bonds. Each naloxegol unit is hydrogen bonded to three hydrogen oxalate ions via two O—H⋯O and one N—H⋯O inter­actions. The resulting hydrogen-bonded two-dimensional layer structure is 3,5-connected and has the >3,5 L50 topology.