首页> 美国卫生研究院文献>OncoTargets and therapy >5-Azacytidine treatment induces demethylation of DAPK1 and MGMT genes and inhibits growth in canine mammary gland tumor cells

【2h】

5-Azacytidine treatment induces demethylation of DAPK1 and MGMT genes and inhibits growth in canine mammary gland tumor cells

机译：5-氮杂胞苷处理可诱导DAPK1和MGMT基因去甲基化并抑制犬乳腺肿瘤细胞的生长

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

BackgroundCanine mammary gland tumors (CMGTs) are the most common, spontaneous types of neoplasias in female dogs. Aberrant DAPK1 and MGMT methylation associated with tumor formation and development in various cancers. 5-Azacytidine is a known specific demethylation drug that covalently binds to DNA methyltransferase. However, the methylation of the DAPK1 and MGMT is unknown with respect to CMGTs. Therefore, we sought to demonstrate the effects of 5-azacytidine on the proliferation of CMGTs cell, and elucidate the potential molecular mechanisms of action in these cancerous cells.

机译：背景犬乳腺肿瘤（CMGT）是雌性狗中最常见的自发性瘤形成类型。 DAPK1和MGMT甲基化异常与各种癌症中的肿瘤形成和发展有关。 5-氮杂胞苷是已知的特异性脱甲基药物，其与DNA甲基转移酶共价结合。但是，对于CMGT，DAPK1和MGMT的甲基化是未知的。因此，我们试图证明5-氮杂胞苷对CMGTs细胞增殖的影响，并阐明在这些癌细胞中潜在的分子作用机理。

著录项

期刊名称 OncoTargets and therapy
作者
Xiaoli Ren; Huatao Li; Xianyi Song; Yuhong Wu; Yun Liu;
展开▼
作者单位

展开▼
年(卷),期 2018(11),-1
年度 2018
页码 2805–2813
总页数 9
原文格式 PDF
正文语种
中图分类应用微生物学 ; 肿瘤学 ;
关键词
canine mammary gland tumor CHMm CHMp 5-azacytidine DAPK1 MGMT DNA methylation;

机译：犬乳腺肿瘤;CHMm;CHMp;5-氮杂胞苷;DAPK1;MGMT;DNA甲基化;

相似文献

外文文献
中文文献
专利

1. 5-Azacytidine treatment induces demethylation of DAPK1 and MGMT genes and inhibits growth in canine mammary gland tumor cells [J] . Xiaoli Ren, Huatao Li, Xianyi Song, OncoTargets and therapy . 2018 ,第2期

机译：5-氮杂胞苷处理诱导 DAPK1 和 MgMT 基因的去甲基化，并抑制犬乳腺肿瘤细胞的生长

2. The DNA methylation inhibitor 5-aza-2 '-deoxycytidine retards cell growth and alters gene expression in canine mammary gland tumor cells [J] . Ito Tsuyoshi, Kaneda Masahiro The Japanese Journal of Veterinary Research . 2017 ,第3期

机译：DNA甲基化抑制剂5-AZA-2'-丁腈胞苷延迟细胞生长，并改变犬乳腺肿瘤肿瘤细胞中的基因表达

3. Selenium Induces an Anti-tumor Effect Via Inhibiting Intratumoral Angiogenesis in a Mouse Model of Transplanted Canine Mammary Tumor Cells [J] . Li Wenyu, Guo Mengyao, Liu Yuzhu, Biological trace element research . 2016 ,第2期

机译：硒通过抑制犬乳腺肿瘤细胞移植小鼠模型中的肿瘤内血管生成诱导抗肿瘤作用。

4. ANGIOGENESIS AND LYMPHANGIOGENESIS IN TISSUES DEVELOPED IN NUDE MICE XENOGRAFTED WITH TWO CANINE MAMMARY GLAND TUMOR CELL LINES. [C] . Soojung Lee, Takayuki Nakagawa, Nozomi Miyajima, Annual Conference of the Veterinary Cancer Society . 2009

机译：裸鼠卵乳腺肿瘤细胞系裸鼠生殖器中血管生成和淋巴管发生。

5. METABOLIC FACTORS AFFECTING THE ABILITY OF SELENIUM TO INHIBIT THE GROWTH OF CANINE MAMMARY TUMOR CELLS [D] . SANTORO, MAXINE FICO 1987

机译：影响硒抑制犬乳腺肿瘤细胞生长的代谢因素

6. Scorpion Venom Peptide Effects on Inhibiting Proliferation and Inducing Apoptosis in Canine Mammary Gland Tumor Cell Lines [O] . Kamonporn Panja, Supranee Buranapraditkun, Sittiruk Roytrakul, 2021

机译：蝎子毒液肽对犬乳腺肿瘤细胞系抑制增殖和诱导细胞凋亡的影响

7. Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice [O] . Richard Jäger, Ute Herzer, Johannes Schenkel, 1997

机译：Bcl-2的过度表达抑制在阴谋期间的肺泡细胞凋亡，并加速转基因小鼠中的C-MYC诱导的乳腺肿瘤

8. Breast Cancer Prevention by Hormonally Induced Mammary Gland Differentiation: The Role of a Novel Mammary Growth Inhibitor and Differentiation Factor MRG (Addendum) [R] . Shi, Y. E. 2003

机译：通过激素诱导的乳腺分化预防乳腺癌：新型乳腺生长抑制剂和分化因子mRG的作用（附录）

1. 5-氮杂-2′-脱氧胞苷诱导胃癌细胞系中p16和MGMT基因去甲基化并激活其表达 [J] . 孟春风 ,彭过 ,戴冬秋 . 中国医科大学学报 . 2008 ,第004期

2. 5-氮杂胞苷抑制乳腺癌细胞Bcap-37增殖及逆转RASSF1A基因甲基化作用 [J] . 吴丽明 ,杨建平 ,莫先启 . 癌变·畸变·突变 . 2006 ,第005期

3. 5-氮杂胞苷逆转SARI基因甲基化对人乳腺癌细胞生长和侵袭的影响 [J] . 朱文斌 ,孙艳 ,张春晶 . 中国病理生理杂志 . 2019 ,第010期

4. 5-氮杂胞苷对HL60细胞P16、DAPK及MGMT基因甲基化状态影响 [J] . 苏庸春 ,徐红珍 ,于洁 . 重庆医科大学学报 . 2012 ,第10期

5. 天花粉蛋白诱导Syk(L)基因去甲基化抑制喉癌Hep-2细胞生长研究 [J] . 金巧智 ,李志海 ,蔡志毅 . 医学研究杂志 . 2018 ,第003期

6. 5-氮杂-2'-脱氧胞苷、曲古抑菌素A联合化疗对人胃癌细胞生长及MGMT基因表达的影响 [C] . 王海 ,刘永萍 ,盛桂凤 . 2015苏浙皖赣肿瘤内科治疗进展高峰论坛暨江苏省第七次肿瘤化疗与生物治疗学术会议 . 2015

7. 5-氮杂胞苷对犬乳腺肿瘤甲基化相关基因作用的研究 [A] . 宋贤义 . 2013

1. 诱导肿瘤细胞转变为神经元样细胞以抑制肿瘤生长的制剂 [P] . 中国专利： CN110051842A . 2019-07-26

2. 一种低氧靶向肿瘤细胞DNA修复酶MGMT抑制剂及其制备方法与应用 [P] . 中国专利： CN109721603B . 2020.05.19

3. methods to inhibit b cell tumor cell proliferation, to treat a patient having a tumor, to treat a patient having a deregulated taki signaling transduction molecule, to inhibit the growth of a solid tumor, to select a patient having a tumor THAT IS SUSTAINABLE to treatment with a taki inhibitor, to inhibit the proliferation of a cell leukemia and t-cell lymphomas, and to select a mammal having or methods to inhibit the proliferation of b cell tumor cell, to treat a patient having a tumor, to treat a patient having a deregulated tak1 signaling transduction molecule, to inhibit the growth of a solid tumor, to select a patient having a tumor that is susceptible to treatment with a tak1 inhibitor, to inhibit the proliferation of a cell leukemia and t-cell lymphomas, and to select a mammal having or suspected of having a tumor for treatment with a medi inhibitor tak1 [P] . 外国专利： BRPI0714158A2 . 2012-12-25

机译：抑制b细胞肿瘤细胞增殖，治疗患有肿瘤的患者，治疗患有taki信号转导分子失调的患者，抑制实体瘤生长，选择具有治疗可持续性的肿瘤的方法使用taki抑制剂来抑制细胞白血病和t细胞淋巴瘤的增殖，并选择具有抑制b细胞肿瘤细胞增殖的哺乳动物或方法，以治疗患有肿瘤的患者，以治疗患有t细胞淋巴瘤的患者失调的tak1信号转导分子，以抑制实体瘤的生长，选择患有对tak1抑制剂治疗敏感的肿瘤的患者，以抑制细胞白血病和t细胞淋巴瘤的增殖，并选择患有或怀疑患有肿瘤的哺乳动物可使用tak1抑制剂治疗

4. isolated and homologous long tensin (pten-long) human phosphatase polypeptide, pharmaceutical composition, method for treating a solid tumor in an individual, method for inhibiting growth of a solid tumor in an individual, method for inhibiting angiogenesis in a solid tumor in an individual, method for inducing apoptosis of a blood vessel epithelial vascular cell in a solid tumor in an individual, method for treating a solid tumor in an individual, human phosphatase polypeptide and long (pten-long) homologue, pten-long or a fragment enhanced analog thereof, composition, isolated nucleic acid encoding a long (pten-long) homologous human phosphatase polypeptide, expression vector, transformed cell capable of expressing tensin homologous human phosphatase polypeptide long (pten-long), host cell capable of expressing human phosphatase polypeptide and long tensin humolog en-long), process, isolated nucleic acid molecule, isolated antibody, antibody fragment and peptide fragment of sequence [P] . 外国专利： BRPI1005951A2 . 2016-10-11

机译：分离且同源的长肌腱（pten-long）人磷酸酶多肽，药物组合物，个体中治疗实体瘤的方法，个体中抑制实体瘤生长的方法，个体中抑制实体瘤中血管生成的方法，在个体的实体瘤中诱导血管上皮血管细胞凋亡的方法，在个体中治疗实体瘤的方法，人磷酸酶多肽和长（pten-long）同源物，pten-long或片段增强类似物及其组成，组成，编码长（pten-long）同源人磷酸酶多肽的分离核酸，表达载体，能够长表达tensin同源人磷酸酶多肽的转化细胞（pten-long），能够表达人磷酸酶多肽的宿主细胞和长tensin humolog en-long），方法，分离的核酸分子，分离的抗体，序列的抗体片段和肽片段

5. methods of inhibiting cathepsin s chemotherapy-induced up-regulation, cathepsin s expression on the surface of tumor cells and angiogenesis in a cell group, tissue or organ, of treating neoplastic disease and a condition associated with cathepsin s activity in a patient, inducing antibody-dependent cell-mediated cytotoxic reaction against a tumor cell, killing tumor cells, identifying tumor cells in a cell population, and evaluating an individual's tumor cell response in vitro the presence of a chemotherapeutic agent, uses of a cathepsin inhibitor if a chemotherapeutic agent of cathepsin s, an anti-cathepsin s antibody or a fragment thereof and an antibody molecule, pharmaceutical composition, pharmaceutical kit and antibody molecule or a nucleic acid encoding said antibody molecule [P] . 外国专利： BRPI0710055A2 . 2011-08-02

机译：抑制组织蛋白酶化学诱导的上调，组织细胞或组织或器官中肿瘤细胞表面上组织蛋白酶的表达和血管生成的方法，用于治疗肿瘤性疾病和与患者组织蛋白酶活性有关的疾病，并诱导抗体依赖细胞介导的针对肿瘤细胞的细胞毒性反应，杀死肿瘤细胞，鉴定细胞群中的肿瘤细胞，并在体外评估是否存在化学治疗剂的情况下个体的肿瘤细胞反应，如果组织化学治疗剂使用组织蛋白酶抑制剂组织蛋白酶，抗组织蛋白酶抗体或其片段和抗体分子，药物组合物，药物试剂盒和抗体分子或编码所述抗体分子的核酸

相关主题

5-Azacytidine treatment induces demethylation of DAPK1 and MGMT genes and inhibits growth in canine mammary gland tumor cells

摘要

著录项

相似文献

相关主题

期刊订阅