P04.36 Technology for the research of Primary and Partially Passaged Cell Cultures by Human Glioblastoma is necessary for studying the characteristics of a tumor and searching for therapy

摘要

BackgroundGlioblastoma is a heterogeneous brain tumor that can be characterized as a socially significant disease with a high mortality threshold. It is believed that the survival prognosis of patients with this diagnosis is extremely unfavorable with an average survival time of only 12–15 months. It should be recognized that the search for new approaches to the study of glioblastoma, which would allow the development of more successful methods of treating this disease, is topical. One of the research areas can be considered the cultivation of cell cultures obtained after surgical removal of the human glioblastoma. It is clear that such cultures are more similar in cellular composition to glioblastoma than cellular immortalized lines. On such cultures, it becomes possible to evaluate both the molecular status of the cell culture and the effectiveness of chemotherapy and radiation.