P08.59 Detection of p53 mutations in proliferating vascular cells in glioblastoma multiforme

摘要

Introduction:Glioblastoma multiforme (GBM), is highly angiogenic. However,treatment with the angiogenesis inhibitor bevacizumab has not significantly prolonged overall survival. GBM resistance to angiogenesis inhibitors is attributed to multiple interacting mechanisms. Although mesenchymal transition via glioma stem-like cells has attracted attention, there is no simple method for differentiating tumor-derived and reactive vascular cells from normal cells.