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A Ratiometric Fluorescent Nano-Probe for Rapid and Specific Detection of Tetracycline Residues Based on a Dye-Doped Functionalized Nanoscaled Metal–Organic Framework

机译:基于染料掺杂的功能化纳米级金属-有机框架的比率荧光纳米探针用于快速特异性地检测四环素残留

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摘要

Tetracycline (TC) residues are harmful to the environment and human body, so it is necessary to develop a highly sensitive probe for rapid detection of tetracycline residues. In the present paper, a novel dye-doped porous metal–organic framework (UiO-66)-based multi-color fluorescent nano-probe was designed for sensitive ratiometric detection of tetracycline (TC). In this probe, dye-molecules doped UiO-66 was used as a fluorescent internal standard, and the externally grafted lanthanide Eu3+ complex was used as response signals. The fluorescence of the Eu3+ complex was selectively enhanced with increasing concentrations of TC, which was accompanied by a visual blue-to-red color switch. The nano-probe had a linear response between 0.1 and 6 μM with a lowest detection limit of 17.9 nM, which was much lower than the maximum residue limits set by the United States Food and Drug Administration (676 nM) and the European Union (225 nM). The applicability of this method in the analysis of actual samples was evaluated by the determination of TC in honey and milk samples, indicating satisfactory recovery and good reproducibility. In addition, a cost-effective paper-based probe for rapid and visual detection of TC was developed by fixing the nano-probe on filter papers. With the help of a smartphone camera to capture the fluorescence color, and chromaticity analysis software, the calculation and analysis of red (R) and blue (B) values can be realized, which has the potential for real-time visual detection of TC.
机译:四环素(TC)残留物对环境和人体有害,因此有必要开发一种高度灵敏的探针来快速检测四环素残留物。在本文中,设计了一种新颖的基于染料掺杂的多孔金属有机框架(UiO-66)的多色荧光纳米探针,用于四环素(TC)的灵敏比例检测。在该探针中,染料分子掺杂的UiO-66被用作荧光内标,外部接枝的镧系元素Eu 3 + 络合物被用作响应信号。 Eu 3 + 配合物的荧光随TC浓度的增加而选择性增强,并伴有可见的蓝到红颜色转换。纳米探针的线性响应介于0.1和6μM之间,最低检测限为17.9 nM,远低于美国食品药品管理局(676 nM)和欧盟(225)设置的最大残留限。 nM)。通过测定蜂蜜和牛奶样品中的TC来评估该方法在实际样品分析中的适用性,表明回收率令人满意且重现性良好。此外,通过将纳米探针固定在滤纸上,开发了一种经济高效的纸质探针,可快速,直观地检测TC。借助智能手机摄像头捕获的荧光色和色度分析软件,可以实现红色(R)和蓝色(B)值的计算和分析,这可能对TC进行实时视觉检测。

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