An Efficient Chemical Synthesis of Scutellarein: An in Vivo Metabolite of Scutellarin

摘要

Scutellarein (>2), which is an important in vivo metabolite of scutellarin (>1), was synthesized from 3,4,5-trimethoxyphenol (>3) in high yield in four steps. This strategy relies on acetylation, aldolization, cyclization and hydrolysis reactions, respectively.