Alkaloids Isolated from the Lateral Root of Aconitum carmichaelii

摘要

Two new alkaloids, aconicarmine (>1) and aconicaramide (>5), were isolated from the EtOH extract of the lateral roots of Aconitum carmichaelii, together with five known compounds: fuziline (>2), neoline (>3), N-ethylhokbusine B (>4), 5-hydroxymethylpyrrole-2-carbaldehyde (>6), and oleracein E (>7). Their structures were elucidated by physical and NMR analysis. Pyrrole alkaloids were isolated from A. carmichaelii for the first time. In the in vitro assays, compounds >2 and >3 showed activity against pentobarbital sodium-induced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability, while compounds >5 and >7 showed moderate antibacterial activity.