Aconicarmisulfonine A, a Sulfonated C₂₀-Diterpenoid Alkaloid from the Lateral Roots of Aconitum carmichaelii

摘要

A novel sulfonated C_(20)-diterpenoid alkaloid with an unprecedented carbon skeleton and significant analgesic activity (46.7% inhibition at 0.1 mg/kg, i.p.), named aconicarmisulfonine A ( 1 ), was isolated from an aqueous extract of the lateral roots of Aconitum carmichaelii . Its structure was determined by comprehensive analysis of spectroscopic data, especially by 2D NMR spectroscopic data combined with ECD calculation and single-crystal X-ray diffraction. The plausible biosynthetic pathways of compound 1 are also discussed.