The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR

摘要

Isolation of compounds from the root of Rhodiola sachalinensis (RRS) yielded tyrosol (>1), salidroside (>2), multiflorin B (>3), kaempferol-3,4′-di-O-β-D-glucopyranoside (>4), afzelin (>5), kaempferol (>6), rhodionin (>7), and rhodiosin (>8). Quantification of these compounds was performed by high-performance liquid chromatography (HPLC). To investigate the antioxidant and anti-inflammatory effects of the compounds, DPPH radical scavenging, NBT superoxide scavenging and nitric oxide production inhibitory activities were examined in LPS-stimulated Raw 264.7 cells. We suggest that the major active components of RRS are herbacetin glycosides, exhibiting antioxidant activity, and kaempferol, exhibiting anti-inflammatory activity.