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Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity

机译：人类脂肪组织中的全基因组DNA启动子甲基化和转录组分析揭示了肥胖的新候选基因

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摘要

Objective/methodsDNA methylation plays an important role in obesity and related metabolic complications. We examined genome-wide DNA promoter methylation along with mRNA profiles in paired samples of human subcutaneous adipose tissue (SAT) and omental visceral adipose tissue (OVAT) from non-obese vs. obese individuals.

机译：目的/方法DNA甲基化在肥胖症和相关的代谢并发症中起重要作用。我们检查了非肥胖与肥胖个体的人皮下脂肪组织（SAT）和网膜内脏脂肪组织（OVAT）配对样品中的全基因组DNA启动子甲基化以及mRNA谱。

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期刊名称 Molecular Metabolism
作者
Maria Keller; Lydia Hopp; Xuanshi Liu; Tobias Wohland; Kerstin Rohde; Raffaella Cancello; Matthias Klös; Karl Bacos; Matthias Kern; Fabian Eichelmann; Arne Dietrich; Michael R. Schön; Daniel Gärtner; Tobias Lohmann; Miriam Dreßler; Michael Stumvoll; Peter Kovacs; Anna-Maria DiBlasio; Charlotte Ling; Hans Binder; Matthias Blüher; Yvonne Böttcher;
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年(卷),期 2017(6),1
年度 2017
页码 86–100
总页数 15
原文格式 PDF
正文语种
中图分类分子生物学;
关键词
DNA methylation Epigenetic mechanisms Human adipose tissue depots mRNA expression Obesity-related co-morbidities;

机译：DNA甲基化;表观遗传机制;人类脂肪组织贮备库;mRNA表达;与肥胖相关的合并症;

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专利

1. Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity [J] . Maria Keller, Lydia Hopp, Xuanshi Liu, Molecular Metabolism . 2017,第1期

机译：人类脂肪组织中的全基因组DNA启动子甲基化和转录组分析揭示了肥胖的新候选基因
2. DNA methylation map in circulating leukocytes mirrors subcutaneous adipose tissue methylation pattern: a genome-wide analysis from non-obese and obese patients [J] . A. B. Crujeiras, A. Diaz-Lagares, J. Sandoval, Scientific reports. . 2017,第1期

机译：DNA甲基化图在循环白细胞反映皮下脂肪组织甲基化模式：非肥胖和肥胖患者的基因组分析
3. An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss [J] . Miles C Benton, Alice Johnstone, David Eccles, Genome Biology . 2015,第1期

机译：对人体脂肪组织中DNA甲基化的分析表明，肥胖基因在胃旁路术和减肥前后的差异得到修饰
4. Genome-wide DNA methylation analysis in tumor and normal tissues from lung squamous cell carcinoma and serous cystadenocarcinoma [C] . 2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops . 2010

机译：肺鳞状细胞癌和浆液性囊腺癌的肿瘤和正常组织中全基因组DNA甲基化分析
5. Intrauterine growth restriction and docosahexanoic acid supplementation alter DNA methylation of the peroxisome proliferator activated receptor gamma promoter 2 in rat visceral adipose tissue. [D] . Heglas, Andrea Marie. 2012

机译：宫内生长受限和二十二碳六烯酸的添加改变了大鼠内脏脂肪组织中过氧化物酶体增殖物激活的受体γ启动子2的DNA甲基化。
6. DNA methylation map in circulating leukocytes mirrors subcutaneous adipose tissue methylation pattern: a genome-wide analysis from non-obese and obese patients [O] . A. B. Crujeiras, A. Diaz-Lagares, J. Sandoval, -1

机译：循环白细胞中的DNA甲基化图反映了皮下脂肪组织的甲基化模式：非肥胖和肥胖患者的全基因组分析
7. Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity [O] . Maria Keller, Lydia Hopp, Xuanshi Liu, 2017

机译：人类脂肪组织中的全基因组DNa启动子甲基化和转录组分析揭示了肥胖的新候选基因

Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity

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