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MiR-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma

机译：MiR-23a介导的对拓扑异构酶1表达的抑制作用增强了人类肝细胞癌中对依托泊苷的细胞应答

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摘要

BackgroundmicroRNAs have been shown to regulate the chemosensitivity of cancer cells. The aim of this study is to investigate the role and mechanism of mir-23a in enhancing the anti-tumor effect of topoisomerase 2A (TOP2A) poison etoposide in human hepatocellular carcinoma (HCC).

机译：背景微RNA已经显示出调节癌细胞的化学敏感性。本研究的目的是研究mir-23a在增强拓扑异构酶2A（TOP2A）毒依托泊苷在人类肝细胞癌（HCC）中的抗肿瘤作用。

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期刊名称 Molecular Cancer
作者
Ning Wang; Meifen Zhu; Sai-Wah Tsao; Kwan Man; Zhangjin Zhang; Yibin Feng;
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作者单位

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年(卷),期 2013(12),-1
年度 2013
页码 119
总页数 10
原文格式 PDF
正文语种
中图分类分子生物学;肿瘤学;
关键词
miR-23a Topoisomerase 1 Etoposide Hepatocellular carcinoma DNA damage;

机译：miR-23a;拓扑异构酶1;依托泊苷;肝细胞癌;DNA损伤;

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专利

1. MiR-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma [J] . Ning Wang, Meifen Zhu, Sai-Wah Tsao, Molecular Cancer . 2013,第1期

机译：MiR-23a介导的对拓扑异构酶1表达的抑制增强了人类肝细胞癌中对依托泊苷的细胞应答。
2. Inhibition of autophagy potentiates the proliferation inhibition activity of microRNA-7 in human hepatocellular carcinoma cells [J] . Wang Yanna, Wang Qiaoling, Song Jiqing Oncology letters . 2017,第3aPta2期

机译：抑制自噬增强了人肝细胞癌细胞中microRNA-7的增殖抑制活性
3. Quercetin-3-O-glucoside induces human DNA topoisomerase II inhibition, cell cycle arrest and apoptosis in hepatocellular carcinoma cells. [J] . Sudhanshu Sudan, H P Vasantha Rupasinghe Anticancer Research: International Journal of Cancer Research and Treatment . 2014,第4期

机译：槲皮素-3-O-葡糖苷诱导人DNA拓扑异构酶II抑制，细胞周期停滞和肝细胞癌细胞凋亡。
4. Gene Expression Differences of TNBG on Human Hepatocellular Carcinoma Cell Line QGY-7701 with cDNAMicroarray [C] . Annual Conference for Young Scientists of China Association for Science and Technology; 20041120-23; Shanghai(CN) . 2004

机译：cDNA微阵列检测TNBG在人肝癌细胞QGY-7701上的基因表达差异
5. Mechanistic Study of the Effect of CDH1 Promoter Hypermethylation on Drug Resistance and Related Gene Expression in Multidrug Resistant Human Hepatocellular Carcinoma R-HepG2 Cells. [D] . Jiang, Lei. 2010

机译：CDH1启动子甲基化对多药耐药人肝细胞癌R-HepG2细胞耐药性及相关基因表达影响的机理研究。
6. Inhibition of autophagy potentiates the proliferation inhibition activity of microRNA-7 in human hepatocellular carcinoma cells [O] . Yanna Wang, Qiaoling Wang, Jiqing Song -1

机译：抑制自噬可增强microRNA-7在人肝癌细胞中的增殖抑制活性
7. MiR-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma [O] . Ning Wang, Meifen Zhu, Sai-Wah Tsao, 2013

机译：MiR-23a介导的对拓扑异构酶1表达的抑制作用增强了人类肝细胞癌中对依托泊苷的细胞应答

MiR-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma

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