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Looking for combination of benznidazole and Trypanosoma cruzi-triosephosphate isomerase inhibitors for Chagas disease treatment

机译：寻找苯并硝唑和克氏锥虫三糖磷酸异构酶抑制剂的组合以治疗南美锥虫病

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BACKGROUNDThe current chemotherapy for Chagas disease is based on monopharmacology with low efficacy and drug tolerance. Polypharmacology is one of the strategies to overcome these limitations.

机译：背景技术当前用于查加斯病的化学疗法是基于单一药理学的，其疗效和药物耐受性低。多元药理学是克服这些局限性的策略之一。

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期刊名称 Memrias do Instituto Oswaldo Cruz
作者
Elena Aguilera; Javier Varela; Elva Serna; Susana Torres; Gloria Yaluff; Ninfa Vera de Bilbao; Hugo Cerecetto; Guzmán Alvarez; Mercedes González;
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作者单位

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年(卷),期 2018(113),3
年度 2018
页码 153–160
总页数 8
原文格式 PDF
正文语种
中图分类寄生动物、寄生虫学;医学寄生虫学;
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专利

1. Looking for combination of benznidazole and Trypanosoma cruzi-triosephosphate isomerase inhibitors for Chagas disease treatment [J] . Aguilera Elena, Varela Javier, Serna Elva, Memorias do Instituto Oswaldo Cruz . 2018,第3期

机译：寻找苯并硝唑和克氏锥虫三糖磷酸异构酶抑制剂的组合以治疗南美锥虫病
2. Impact of benznidazole treatment on the functional response of Trypanosoma cruzi antigen-specific CD4+CD8+ T cells in chronic Chagas disease patients [J] . Elena Pérez-Antón, Adriana Egui, M. Carmen Thomas, PLOS Neglected Tropical Diseases . 2018,第5期

机译：苯并硝唑治疗对慢性恰加斯病患者锥虫锥虫抗原特异性CD4 + CD8 + T细胞功能反应的影响
3. Benznidazole therapy for Chagas disease in asymptomatic Trypanosoma cruzi -seropositive former blood donors: evaluation of the efficacy of different treatment regimens [J] . Antunes Andr?? Pires, Ribeiro Ant?′nio Luiz Pinho, Sabino Ester Cerdeira, Sociedade Brasileira de Medicina Tropical. Revista . 2016,第6期

机译：苯硝唑治疗无症状克鲁斯锥虫血清阳性前供血者的南美锥虫病：不同治疗方案的疗效评估
4. Effect of TGF-beta and TNF-alpha treatment in Trypanosoma cruzi-infected cardiomyocytes: new insights on Chagas' disease extracellular matrix regulation [C] . Calvet C.M, Oliveira, F.O.R., International Congress of Parasitology . 2010

机译：TGF-β和TNF-α治疗在脑瘤瘤瘤瘤感染心肌细胞中的影响：对黏磁疾病细胞外基质调节的新见解
5. Synthesis of Trypanosoma cruzi Lanosterol 14alpha Demethylase (TcCYP51) Inhibitors for the Treatment of Chagas Disease. [D] . Clements, Zeke T. 2014

机译：合成锥虫锥虫Lanosterol 14alpha脱甲基酶（TcCYP51）抑制剂，用于治疗南美锥虫病。
6. Benznidazole/Itraconazole Combination Treatment Enhances Anti-Trypanosoma cruzi Activity in Experimental Chagas Disease [O] . Tassiane Assíria Fontes Martins, Lívia de Figueiredo Diniz, Ana Lia Mazzeti, -1

机译：苯并咪唑/伊曲康唑联合治疗可增强实验性恰加斯病中的克鲁氏锥虫活性
7. Looking for combination of benznidazole and Trypanosoma cruzi-triosephosphate isomerase inhibitors for Chagas disease treatment [O] . Elena Aguilera, Javier Varela, Elva Serna, 2018

机译：寻找苯并咪唑和锥虫瘤克鲁齐 - Triosephate异构酶抑制剂的组合，用于Chagas疾病治疗

Looking for combination of benznidazole and Trypanosoma cruzi-triosephosphate isomerase inhibitors for Chagas disease treatment

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