首页> 美国卫生研究院文献>Therapeutic Advances in Medical Oncology >Downregulation of long noncoding RNA LINC01419 inhibits cell migration invasion and tumor growth and promotes autophagy via inactivation of the PI3K/Akt1/mTOR pathway in gastric cancer

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Downregulation of long noncoding RNA LINC01419 inhibits cell migration invasion and tumor growth and promotes autophagy via inactivation of the PI3K/Akt1/mTOR pathway in gastric cancer

机译：长非编码RNA LINC01419的下调抑制胃癌中的细胞迁移侵袭和肿瘤生长并通过失活PI3K / Akt1 / mTOR途径促进自噬

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摘要

Background:Accumulating evidence has highlighted the crucial role of long noncoding RNAs (lncRNAs) in the tumorigenesis of gastric cancer (GC), which is the most common gastrointestinal malignancy. The present study aimed to identify the capacity of lncRNA LINC01419 (LINC01419) in GC progression, with the potential mechanism explored.

机译：背景：越来越多的证据突出了长非编码RNA（lncRNA）在胃癌（GC）的肿瘤发生中的关键作用，胃癌是最常见的胃肠道恶性肿瘤。本研究旨在确定lncRNA LINC01419（LINC01419）在GC进展中的能力，并探讨了潜在的机制。

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期刊名称 Therapeutic Advances in Medical Oncology
作者
Lin-Lin Wang; Lei Zhang; Xiao-Feng Cui;
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作者单位

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年(卷),期 2019(11),-1
年度 2019
页码 1758835919874651
总页数 16
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词
autophagy gastric cancer invasion and migration LINC01419 long noncoding PI3K/Akt1/mTOR pathway RNA;

机译：自噬;胃癌;侵袭和迁移;LINC01419;长非编码PI3K / Akt1 / mTOR途径;RNA;

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专利

1. Downregulation of long noncoding RNA LINC01419 inhibits cell migration, invasion, and tumor growth and promotes autophagy via inactivation of the PI3K/Akt1/mTOR pathway in gastric cancer [J] . Lin-Lin Wang, Lei Zhang, Xiao-Feng Cui Therapeutic advances in medical oncology. . 2019,第12期

机译：长度非数性RNA LINC01419的下调抑制细胞迁移，侵袭和肿瘤生长，并通过胃癌中的PI3K / AKT1 / mTOR途径的灭活来促进自噬
2. Long noncoding RNA-JPX predicts the poor prognosis of ovarian cancer patients and promotes tumor cell proliferation, invasion and migration by the PI3K/Akt/mTOR signaling pathway [J] . J. Li, L. Feng, C. Tian, European review for medical and pharmacological sciences. . 2018,第23期

机译：较长的非编码RNA-JPX通过PI3K / Akt / mTOR信号通路预测卵巢癌患者预后不良，并促进肿瘤细胞增殖，侵袭和迁移
3. Long noncoding RNA-JPX predicts the poor prognosis of ovarian cancer patients and promotes tumor cell proliferation, invasion and migration by the PI3K/Akt/mTOR signaling pathway [J] . J. Li, L. Feng, C. Tian, European review for medical and pharmacological sciences. . 2018,第23期

机译：较长的非编码RNA-JPX通过PI3K / Akt / mTOR信号通路预测卵巢癌患者预后不良，并促进肿瘤细胞增殖，侵袭和迁移
4. Label-free phosphoproteomics method to investigate signaling pathways downstream of novel PI3K/mTOR inhibitors in cancer cells [C] . Pedro Casado, Juan Carlos Rodriguez-Prados, Sabina Cosulich, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：无标记的磷蛋白质方法，用于研究新型PI3K / MTOR抑制剂在癌细胞中的信号通路
5. Induction of apoptosis and autophagy by the small molecule inhibitor VMY-1-103 in cancer cell lines and reduction of tumor growth in vivo. [D] . Sirajuddin, Paul. 2013

机译：小分子抑制剂VMY-1-103在癌细胞系中诱导凋亡和自噬，并降低体内肿瘤的生长。
6. Sinulariolide Inhibits Gastric Cancer Cell Migration and Invasion through Downregulation of the EMT Process and Suppression of FAK/PI3K/AKT/mTOR and MAPKs Signaling Pathways [O] . Yu-Jen Wu, Shih-Hsiung Lin, Zhong-Hao Din, 2019

机译：Sinulariolide通过下调EMT过程以及抑制FAK / PI3K / AKT / mTOR和MAPKs信号通路抑制胃癌细胞的迁移和侵袭
7. Downregulation of long noncoding RNA LINC01419 inhibits cell migration, invasion, and tumor growth and promotes autophagy via inactivation of the PI3K/Akt1/mTOR pathway in gastric cancer [O] . Lin-Lin Wang, Lei Zhang, Xiao-Feng Cui 2019

机译：长度非数性RNA LINC01419的下调抑制细胞迁移，侵袭和肿瘤生长，并通过胃癌中的PI3K / AKT1 / mTOR途径的灭活来促进自噬

Downregulation of long noncoding RNA LINC01419 inhibits cell migration invasion and tumor growth and promotes autophagy via inactivation of the PI3K/Akt1/mTOR pathway in gastric cancer

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