Indications that codon boundaries are physico-chemically defined and that protein-folding information is contained in the redundant exon bases

摘要

BackgroundAll the information necessary for protein folding is supposed to be present in the amino acid sequence. It is still not possible to provide specific ab initio structure predictions by bioinformatical methods. It is suspected that additional folding information is present in protein coding nucleic acid sequences, but this is not represented by the known genetic code.