首页> 美国卫生研究院文献>Lipids in Health and Disease >Comparative study on the independent and combined effects of omega-3 and vitamin B12 on phospholipids and phospholipase A2 as phospholipid hydrolyzing enzymes in PPA-treated rats as a model for autistic traits
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Comparative study on the independent and combined effects of omega-3 and vitamin B12 on phospholipids and phospholipase A2 as phospholipid hydrolyzing enzymes in PPA-treated rats as a model for autistic traits

机译:Omega-3和维生素B12对PPA治疗的大鼠自闭症性状模型中磷脂和磷脂酶A2作为磷脂水解酶的独立和联合作用的比较研究

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摘要

BackgroundAbnormal phospholipid metabolism is a major component of many neurodevelopmental disorders including autism. Oral administration of propionic acid (PPA) can produce behavioral abnormalities and biochemical features in rodents similar to those observed in autism and can thus be used as a model to understand impaired brain fatty acid metabolism in autism.
机译:背景磷脂代谢异常是许多神经发育障碍(包括自闭症)的主要组成部分。口服丙酸(PPA)可以在啮齿动物中产生行为异常和生化特征,类似于自闭症中观察到的行为,因此可以用作了解自闭症中脑脂肪酸代谢受损的模型。

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